Cardiovascular advantages among the offspring of centenarians.
Cardiovascular advantages among the offspring of centenarians.
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DOI：
10.1093/gerona/58.5.m425
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发表时间：
2003-05
期刊：
影响因子：
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通讯作者：
Dellara F. Terry;M. Wilcox;M. McCormick;Elizabeth V. Lawler;T. Perls
中科院分区：
文献类型：
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作者：
Dellara F. Terry;M. Wilcox;M. McCormick;Elizabeth V. Lawler;T. Perls
背景技术 能够活到异常晚年的能力的一个重要组成部分可能是家族的。这项研究评估了百岁老人后代中与年龄相关的疾病的患病率。方法 采用横断面研究设计，对 1997 年至 2000 年百岁老人后代 (n=177) 和对照组 (n=166) 的健康史进行评估。招募并登记了参加全国新英格兰百岁老人研究的 192 名百岁老人的后代。对照组由父母与百岁老人同年出生的后代组成，但其中至少有一名在平均预期寿命内死亡。比较两组与年龄相关的疾病的患病率，包括心脏病、高血压、糖尿病、癌症、骨质疏松症、中风、痴呆、白内障、青光眼、黄斑变性、抑郁症、帕金森病、甲状腺疾病和慢性阻塞性肺病。结果 百岁后代心脏病的相对患病率降低了 56%（比值比 [OR] 0.44，95% 置信区间 [CI] 0.24, 0.80），高血压的相对患病率降低了 66%（OR 0.34，95% CI 0.21, 0.55），糖尿病的相对患病率降低了 59%（OR 0.41，95% CI） 0.15，1.12）经过多变量调整分析后。结论 百岁老人的后代与衰老相关的疾病患病率显着降低，特别是心血管疾病和心血管危险因素。 70多岁和80多岁的百岁老人后代和他们的父母一起，可能是研究有助于健康长寿的遗传和环境因素的有价值的群体。
BACKGROUND A significant component of the ability to survive to exceptional old age may be familial. This study assessed the prevalence of age-related diseases in the offspring of centenarians. METHODS The health histories of centenarian offspring (n=177) and controls (n=166) were assessed from 1997-2000 using a cross-sectional study design. The offspring of 192 centenarian subjects enrolled in the nationwide New England Centenarian Study were recruited and enrolled. Controls consisted of offspring whose parents were born in the same years as the centenarians but at least 1 of whom died at an average life expectancy. Prevalence of age-related diseases including heart disease, hypertension, diabetes, cancer, osteoporosis, stroke, dementia, cataracts, glaucoma, macular degeneration, depression, Parkinson's disease, thyroid disease, and chronic obstructive pulmonary disease were compared between the two groups. RESULTS Centenarian offspring had a 56% reduced relative prevalence of heart disease (odds ratio [OR] 0.44, 95% confidence interval [CI] 0.24, 0.80), a 66% reduced relative prevalence of hypertension (OR 0.34, 95% CI 0.21, 0.55), and 59% reduced relative prevalence of diabetes (OR 0.41, 95% CI 0.15, 1.12) after multivariate adjusted analyses. CONCLUSIONS The offspring of centenarians demonstrate a markedly reduced prevalence of diseases associated with aging, in particular for cardiovascular disease and cardiovascular risk factors. Along with their parents, the centenarian offspring, who are in their 70s and 80s, may prove to be a valuable cohort to study genetic and environmental factors conducive to the ability to live to very old age in good health.