Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System
Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System
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DOI：
10.1007/s10439-010-9955-z
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发表时间：
2010-05-01
影响因子：
3.8
通讯作者：
Childress, Emily
中科院分区：
文献类型：
--
作者：
Basciano, Christopher A.;Kleinstreuer, Clement;Childress, Emily
通过钇-90（Y-90）放射性栓塞治疗肝肿瘤是不可切除肝肿瘤的可行治疗选择。使用临床Y-90微粒（即，SIR-Spheres（A（R））和TheraSpheres（A（R）在代表性肝动脉系统的计算模型中，模拟层流瞬态3D粒子血流动力学。具体而言，确定了微球在右肝（载瘤）动脉中的最佳颗粒释放位置以及最佳时间释放窗口，以离开可能与肝肿瘤相连的特定出口子血管。结果表明，弯曲的几何形状的速度场和粒子的轨迹依赖于空间和时间的粒子喷射条件的影响。SIR-Spheres（A（R））和TheraSpheres（A（R））的不同物理颗粒特性对动脉脉搏的减速部分中的颗粒轨迹具有微妙的影响，即，当作用在粒子上的惯性力较弱时。相反，颗粒特性和非弹性壁碰撞对动脉脉搏加速阶段释放的颗粒几乎没有影响，即，两种类型的微球都沿着有组织的路径到达预定的出口。这样的结果开始为将100%释放的微球导向特定的子血管（例如，那些连接到肿瘤的）在瞬时流动条件下通过新的药物-颗粒靶向方法以真实的几何形状。
Combating liver tumors via yttrium-90 (Y-90) radioembolization is a viable treatment option of nonresectable liver tumors. Employing clinical Y-90 microparticles (i.e., SIR-Spheres(A (R)) and TheraSpheres(A (R))) in a computational model of a representative hepatic artery system, laminar transient 3D particle-hemodynamics were simulated. Specifically, optimal particle release positions in the right hepatic (parent) artery as well as the best temporal release window were determined for the microspheres to exit specific outlet daughter vessels, potentially connected to liver tumors. The results illustrate the influence of a curved geometry on the velocity field and the particle trajectory dependence on the spatial and temporal particle injection conditions. The differing physical particle characteristics of the SIR-Spheres(A (R)) and the TheraSpheres(A (R)) had a subtle impact on particle trajectories in the decelerating portion of the arterial pulse, i.e., when the inertial forces on the particles are weaker. Conversely, particle characteristics and inelastic wall collisions had little effect on particles released during the accelerating phase of the arterial pulse, i.e., both types of microspheres followed organized paths to predetermined outlets. Such results begin paving the way towards directing 100% of the released microspheres to specific daughter vessels (e.g., those connected to tumors) under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology.