Soda stream modifies airway fluid.
Soda stream modifies airway fluid.
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苏打水流可以改变气道液体。
DOI：
10.1113/jp280467
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Parker,MarkD
中科院分区：
文献类型：
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作者：
Parker,MarkD
下呼吸道的传导通道涂有气道表面液体（ASL）。ASL有两个组成部分：粘液的外部凝胶层和睫状体周围液体的下层水层。粘液层捕获吸入的颗粒和病原体，并通过将粘液向喉咙移动的纤毛（粘膜纤毛清除）为它们的排出提供载体。下面的纤毛周液使粘液水合，提供了纤毛可以跳动的大部分无粘液区，充当粘液和道壁之间的润滑剂，并含有许多抗微生物因子（Fahy & Dickey，2010）。ASL的关键参数是其碳酸氢盐浓度（[HCO 3-]），其通过限制ASL酸化降低粘液粘度并促进局部病原体防御系统的功效（Shin等人，2020年）。事实上，酸性ASL是几种肺部疾病（例如，哮喘、囊性纤维化：（Hunt & Gaston，2013））的恶化特征，并且气道碱化已经成为一种有前景的治疗策略（Alaiwa et al.，2016; Delpiano等人，2018年）。Thornell等人在最新一期的《生理学杂志》上发表了一篇论文。（2020）扩大了我们对控制纤毛周围的机制的了解，因此ASL，[HCO 3-]和pH值。
The conducting passages of the lower respiratory tract are coated with airway surface liquid (ASL). ASL has two components: an outer gel layer of mucus and an underlying aqueous layer of periciliary fluid. The mucus layer traps inhaled particles and pathogens and provides a vehicle for their expulsion by tract-lining cilia that move the mucus out towards the throat (mucociliary clearance). The periciliary fluid beneath hydrates the mucus, provides a largely mucus-free zone in which the cilia can beat, acts as a lubricant between the mucus and the tract wall, and contains a number of antimicrobial factors (Fahy & Dickey, 2010). A critical parameter of ASL is its bicarbonate concentration ([HCO3–]) which, by limiting ASL acidification, lowers mucus viscosity and promotes the efficacy of local pathogen defense systems (Shin et al., 2020). Indeed, acidic ASL is an exacerbating feature of several lung diseases (eg, asthma, cystic fibrosis:(Hunt & Gaston, 2013)), and airway alkalinization has emerged as a promising therapeutic strategy (Alaiwa et al., 2016; Delpiano et al., 2018). In their paper in the current issue of The Journal of Physiology, Thornell et al.(2020) expand our knowledge of the mechanisms that control periciliary, and therefore ASL,[HCO3–] and pH.