Aqueous ZnCl2 Complex Catalyzed Prins Reaction of Silyl Glyoxylates: Access to Functionalized Tertiary α-Silyl Alcohols
Aqueous ZnCl2 Complex Catalyzed Prins Reaction of Silyl Glyoxylates: Access to Functionalized Tertiary α-Silyl Alcohols
复制标题
水相 ZnCl2 络合物催化乙醛酸甲硅烷基酯的 Prins 反应：获得功能化叔 α-甲硅烷基醇
DOI：
10.1021/acs.joc.9b03501
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发表时间：
2020-05-01
影响因子：
3.6
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Han, Man-Yi;Pan, Hong;Wang, Lei
研究了在ZnCl 2水溶液催化下乙醛酸甲硅烷基酯的Prins反应，在温和条件下以高产率合成了官能化的α-甲硅烷基叔醇。初步研究表明，ZnCl 2水溶液作为Bronsted酸和刘易斯酸的双功能催化剂，通过双活化模型活化乙醛酸硅酯的羰基。
An efficient Prins reaction of silyl glyoxylates in the presence of an aqueous ZnCl2 complex as a catalyst was developed, providing functionalized tertiary alpha-silyl alcohols in high yields under mild conditions. A preliminary investigation indicated that the aqueous ZnCl2 complex acted as a dual functional catalyst of Bronsted and Lewis acid to activate the carbonyl groups of silyl glyoxylates via a dual-activation model.