Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
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作者：
利用对907例儿童急性淋巴细胞白血病（病例）和2,398例对照的全基因组关联研究的数据，并在总计2,386例病例和2,419例对照的样本中进行验证，我们发现9p21.3的常见变异（rs3731217，CDKN 2A内含子1）影响急性淋巴细胞白血病风险（比值比= 0.71，P = 3.01 × 10−11），与细胞谱系无关。
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10−11), irrespective of cell lineage.
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影响因子：
30.8
作者：
Shete S;Hosking FJ;Robertson LB;Dobbins SE;Sanson M;Malmer B;Simon M;Marie Y;Boisselier B;Delattre JY;Hoang-Xuan K;El Hallani S;Idbaih A;Zelenika D;Andersson U;Henriksson R;Bergenheim AT;Feychting M;Lönn S;Ahlbom A;Schramm J;Linnebank M;Hemminki K;Kumar R;Hepworth SJ;Price A;Armstrong G;Liu Y;Gu X;Yu R;Lau C;Schoemaker M;Muir K;Swerdlow A;Lathrop M;Bondy M;Houlston RS
通讯作者：
Houlston RS
影响因子：
11.4
作者：
Iacobucci, I.;Lonetti, A.;Martinelli, G.
通讯作者：
Martinelli, G.
影响因子：
30.8
作者：
Papaemmanuil E;Hosking FJ;Vijayakrishnan J;Price A;Olver B;Sheridan E;Kinsey SE;Lightfoot T;Roman E;Irving JA;Allan JM;Tomlinson IP;Taylor M;Greaves M;Houlston RS
通讯作者：
Houlston RS
影响因子：
30.8
作者：
Stacey, Simon N.;Sulem, Patrick;Masson, Gisli;Gudjonsson, Sigurjon A.;Thorleifsson, Gudmar;Jakobsdottir, Margret;Sigurdsson, Asgeir;Gudbjartsson, Daniel F.;Sigurgeirsson, Bardur;Benediktsdottir, Kristrun R.;Thorisdottir, Kristin;Ragnarsson, Rafn;Scherer, Dominique;Hemminki, Kari;Rudnai, Peter;Gurzau, Eugene;Koppova, Kvetoslava;Botella-Estrada, Rafael;Soriano, Virtudes;Juberias, Pablo;Saez, Berta;Gilaberte, Yolanda;Fuentelsaz, Victoria;Corredera, Cristina;Grasa, Matilde;Hoiom, Veronica;Lindblom, Annika;Bonenkamp, Johannes J.;van Rossum, Michelle M.;Aben, Katja K. H.;de Vries, Esther;Santinami, Mario;Di Mauro, Maria G.;Maurichi, Andrea;Wendt, Judith;Hochleitner, Pia;Pehamberger, Hubert;Gudmundsson, Julius;Magnusdottir, Droplaug N.;Gretarsdottir, Solveig;Holm, Hilma;Steinthorsdottir, Valgerdur;Frigge, Michael L.;Blondal, Thorarinn;Saemundsdottir, Jona;Bjarnason, Hjordis;Kristjansson, Kristleifur;Bjornsdottir, Gyda;Okamoto, Ichiro;Rivoltini, Licia;Rodolfo, Monica;Kiemeney, Lambertus A.;Hansson, Johan;Nagore, Eduardo;Mayordomo, Jose I.;Kumar, Rajiv;Karagas, Margaret R.;Nelson, Heather H.;Gulcher, Jeffrey R.;Rafnar, Thorunn;Thorsteinsdottir, Unnur;Olafsson, Jon H.;Kong, Augustine;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
30.8
作者：
Falchi, Mario;Bataille, Veronique;Hayward, Nicholas K.;Duffy, David L.;Bishop, Julia A. Newton;Pastinen, Tomi;Cervino, Alessandra;Zhao, Zhen Z.;Deloukas, Panos;Soranzo, Nicole;Elder, David E.;Barrett, Jennifer H.;Martin, Nicholas G.;Bishop, D. Timothy;Montgomery, Grant W.;Spector, Timothy D.
通讯作者：
Spector, Timothy D.