Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors
Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors
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DOI：
10.1073/pnas.0908073106
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发表时间：
2009-12-01
影响因子：
11.1
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
--
作者：
Liu, Hesheng;Stufflebeam, Steven M.;Buckner, Randy L.
大脑的偏侧化是人脑的基本特性，也是成功发育的标志。在这里，我们提供的证据表明，多种机制控制不同的大脑系统的不对称性。使用内在活动来测量300名成年人的不对称性，我们绘制了最强烈的侧化大脑区域。男性和女性都表现出强烈的不对称性，具有显著但很小的组间差异。对不对称区域的因素分析显示了4个独立的因素，每个因素都解释了受试者之间的显著差异。这些因素与涉及视觉、内部思维（默认网络）、注意力和语言的大脑系统有关。一个独立的右撇子和左撇子的样本表明，手优势影响大脑的不对称性，但在支持他们的独立性的4个因素之间存在差异。这些研究结果表明，使用内在活动波动测量大脑不对称性的可行性，并表明多种遗传或环境机制控制大脑侧化。
Cerebral lateralization is a fundamental property of the human brain and a marker of successful development. Here we provide evidence that multiple mechanisms control asymmetry for distinct brain systems. Using intrinsic activity to measure asymmetry in 300 adults, we mapped the most strongly lateralized brain regions. Both men and women showed strong asymmetries with a significant, but small, group difference. Factor analysis on the asymmetric regions revealed 4 separate factors that each accounted for significant variation across subjects. The factors were associated with brain systems involved in vision, internal thought (the default network), attention, and language. An independent sample of right-and left-handed individuals showed that hand dominance affects brain asymmetry but differentially across the 4 factors supporting their independence. These findings show the feasibility of measuring brain asymmetry using intrinsic activity fluctuations and suggest that multiple genetic or environmental mechanisms control cerebral lateralization.