A nanoporous gold membrane for sensing applications.
A nanoporous gold membrane for sensing applications.
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DOI：
10.1016/j.sbsr.2016.01.001
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发表时间：
2016-03
影响因子：
5.3
通讯作者：
Melvin T
中科院分区：
文献类型：
--
作者：
Oo SZ;Silva G;Carpignano F;Noual A;Pechstedt K;Mateos L;Grant-Jacob JA;Brocklesby B;Horak P;Charlton M;Boden SA;Melvin T
设计和制造的三维结构，金膜含有六方密堆积的微腔与纳米孔的基础上，描述。我们的目的是创建一种纳米多孔结构，当用大约600 nm的光激发时，在纳米孔处和纳米孔中具有局部增强的荧光或拉曼散射，以期提供对生物分子的灵敏检测。首先从理论上评估了集成到金微腔的六边形紧密堆积组件中的纳米孔的几何形状范围。然后考虑单个微腔中纳米孔的最佳尺寸和形状，以在纳米孔的正中心处为穿过的生物分析物提供最高的局部等离子体增强（荧光或拉曼散射）。优化的设计被建立为600 nm深度的1200 nm直径的腔，其具有在基底中具有圆角的50 nm正方形纳米孔。一个金的三维结构的膜包含这些大小的微腔与集成的纳米孔成功地制造和“概念证明”拉曼散射实验进行了描述。在基底中具有纳米孔的3D结构金微腔膜理论上设计用于等离子体增强检测具有纳米孔的金微腔膜的制造“概念验证”研究显示增强的拉曼散射检测
Design and fabrication of three-dimensionally structured, gold membranes containing hexagonally close-packed microcavities with nanopores in the base, are described. Our aim is to create a nanoporous structure with localized enhancement of the fluorescence or Raman scattering at, and in the nanopore when excited with light of approximately 600 nm, with a view to provide sensitive detection of biomolecules. A range of geometries of the nanopore integrated into hexagonally close-packed assemblies of gold micro-cavities was first evaluated theoretically. The optimal size and shape of the nanopore in a single microcavity were then considered to provide the highest localized plasmon enhancement (of fluorescence or Raman scattering) at the very center of the nanopore for a bioanalyte traversing through. The optimized design was established to be a 1200 nm diameter cavity of 600 nm depth with a 50 nm square nanopore with rounded corners in the base. A gold 3D-structured membrane containing these sized microcavities with the integrated nanopore was successfully fabricated and ‘proof of concept’ Raman scattering experiments are described. 3D structured gold microcavity membrane with a nanopore in the base designed Theoretically for plasmon-enhanced detection Fabrication of gold microcavity membrane with a nanopore ‘Proof of concept’ study showing enhanced Raman scattering detection