Defective processing of contextual information may be involved in the poor performance of DBA/2 mice in spatial tasks
Defective processing of contextual information may be involved in the poor performance of DBA/2 mice in spatial tasks
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DOI：
10.1023/a:1021698408581
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发表时间：
1999-07-01
影响因子：
2.6
通讯作者：
Lassalle, JM
中科院分区：
文献类型：
--
作者：
Ammassari-Teule, M;Milhaud, JM;Lassalle, JM
这些实验检查了上下文操作对C57 BL/6（C57）和DBA/2（DBA）小鼠中的径向迷宫性能的影响。来自每个品系的动物在两种不同的背景下进行训练--结果表明，C57在丰富的线索条件下训练时表现得更好，而DBA在两种条件下都表现不佳。此外，上下文操作被发现在C57比DBA小鼠中产生更剧烈的影响。也就是说，C57表现出强烈的性能递减后，每一个上下文的转变，而DBA小鼠没有。特别是，DBA小鼠在丰富和贫穷的线索条件下表现相似，也反应温和，或没有反应的上下文变化的事实表明，在处理上下文信息，这对他们的能力形成空间表示的重要限制的赤字。
These experiments examine the influence of context manipulations on radial maze performance in C57BL/6 (C57) and DBA/2 (DBA) mice. Animals from each strain were trained in two distinct contexts-poor cuing vs rich cuing-that were sucessively switched. The results first show that C57 performed better when trained under rich cuing conditions than under poor ones, whereas DBA performed poorly under both conditions. In addition, contextual manipulations were found to produce more drastic effects in C57 than in DBA mice. That is, C57 showed a strong performance decrement following each context shift, whereas DBA mice did not. In particular, the fact that DBA mice performed similarly under rich and poor cuing conditions and also reacted mildly-or did not react-to context shifts suggests a deficit in processing contextual information, which places important constraints on their capability to form spatial representations.