Cancer Stem Cells as a Predictive Factor in Radiotherapy
Cancer Stem Cells as a Predictive Factor in Radiotherapy
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DOI：
10.1016/j.semradonc.2011.12.003
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发表时间：
2012-04-01
影响因子：
3.5
通讯作者：
Baumann, Michael
中科院分区：
文献类型：
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作者：
Brunner, Thomas B.;Kunz-Schughart, Leoni A.;Baumann, Michael
癌症干细胞研究是肿瘤学研究中最繁荣和最具竞争力的领域之一，因为它有可能极大地影响临床结果。在血液学进展的引领下，癌症干细胞研究现在已经提供了证据，证明它在实体癌中也发挥着重要作用。由于放射治疗的疗效仅次于手术，因此放射肿瘤学家必须了解癌症干细胞生物学的进展是否能够使他们利用这些知识来帮助治愈更多的癌症患者。本文概述了癌症干细胞概念的挑战，并强调了一些正在深入研究的重要现象，如严峻的表型可塑性和微环境生态位的影响和动态。我们讨论了目前的实验和治疗诊断工具的潜力和局限性，并最终提出了未来研究的议程，作为临床翻译可能性的展望。Semin Radiat Oncol 22：151-174（c）2012 Elsevier Inc. All rights reserved.
Cancer stem cell research is one of the most thriving and competitive areas in oncology research because it has the potential to dramatically affect clinical outcomes. Led by progress in hematology, cancer stem cell research has now provided evidence to play an important role for solid cancers as well. Because radiotherapy is only second to surgery in terms of its curative potency, it is very important for radiation oncologists to learn whether progress in cancer stem cell biology can enable them to exploit this knowledge to help cure more patients suffering from cancer. The present article gives an overview about the challenges of the cancer stem cell concept and highlights some important phenomena that are under intense investigation, such as phenotypic plasticity of sternness and impact and dynamics of microenvironmental niches. We discuss the potential and limitations of current experimental and theragnostic tools and end up with an agenda for future research as outlook for translational possibilities in the clinic. Semin Radiat Oncol 22:151-174 (c) 2012 Elsevier Inc. All rights reserved.