Primary body cavity-based AIDS-related lymphomas.
Primary body cavity-based AIDS-related lymphomas.
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原发性体腔艾滋病相关淋巴瘤。
DOI：
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发表时间：
1996
影响因子：
3.5
通讯作者：
R. Mckenna
中科院分区：
文献类型：
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作者：
M. Ansari;D. Dawson;R. Nador;C. Rutherford;N. Schneider;M. J. Latimer;L. Picker;D. Knowles;R. Mckenna
5例晚期艾滋病患者发展为一种独特的高级别原发性体腔非霍奇金淋巴瘤（NHL）。淋巴瘤仅发生在浆液性积液中，体腔内未发现肿块性疾病，无淋巴结病或器官肿大。所有淋巴瘤表现出几乎相同的形态，不能精确分类，但似乎是大细胞免疫母细胞淋巴瘤和间变性大细胞淋巴瘤的桥梁特征。免疫表型上，淋巴瘤细胞不表达任何B淋巴细胞或t淋巴细胞抗原，但表达CD45和活化抗原CD30、CD38、CD71和HLA-DR。克隆重排免疫球蛋白重链和kappa轻链基因经Southern blot鉴定。分子研究还揭示了爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV）的基因组和c-myc原癌基因的种系结构。在两例细胞遗传学研究中，淋巴瘤细胞表现出复杂的染色体异常。这些淋巴瘤在临床和生物学上都是独特的，主要发生在晚期艾滋病患者中，在许多病例中已有卡波西氏肉瘤。
Five patients with advanced AIDS developed a unique type of high grade primary body cavity-based non-Hodgkin's lymphoma (NHL). The lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organomegaly. All of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. Immunophenotypically the lymphoma cells lacked expression of any B- or T-lymphocyte antigens, but expressed CD45 and the activation antigens CD30, CD38, CD71, and HLA-DR. Clonally rearranged immunoglobulin heavy chain and kappa light chain genes were identified by Southern blot analysis. Molecular studies also revealed Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) genomes and germline configuration of the c-myc protooncogene. In two cases studied cytogenetically, the lymphoma cells manifested complex chromosome abnormalities. These lymphomas are clinically and biologically unique and found predominantly in patients with advanced AIDS, in many cases with pre-existing Kaposi's sarcoma.