Chemosensitive serotonergic neurons are closely associated with large medullary arteries
Chemosensitive serotonergic neurons are closely associated with large medullary arteries
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DOI：
10.1038/nn848
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发表时间：
2002-05-01
影响因子：
25
通讯作者：
Richerson, GB
中科院分区：
文献类型：
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作者：
Bradley, SR;Pieribone, VA;Richerson, GB
我们之前已经证明，二氧化碳的增加会强烈刺激髓质的血清素能神经元，这表明它们是中枢呼吸化学感受器。在这里，我们使用共聚焦成像和电子显微镜来显示对色氨酸羟化酶（TpOH）具有免疫反应性的神经元与大鼠髓质中的大动脉紧密相连。我们使用脑切片的膜片钳记录来确认具有这种解剖特化的神经元对化学敏感。血清素能神经元是感知动脉血二氧化碳的理想位置，并且可能通过对大脑功能的广泛影响来帮助维持 pH 稳态。这里报告的结果支持最近的一项提议，即婴儿猝死综合症（SIDS）是由髓质血清素神经元发育异常引起的。
We have previously shown that serotonergic neurons of the medulla are strongly stimulated by an increase in CO2, suggesting that they are central respiratory chemoreceptors. Here we used confocal imaging and electron microscopy to show that neurons immunoreactive for tryptophan hydroxylase (TpOH) are tightly apposed to large arteries in the rat medulla. We used patch-clamp recordings from brain slices to confirm that neurons with this anatomical specialization are chemosensitive. Serotonergic neurons are ideally situated for sensing arterial blood CO2, and may help maintain pH homeostasis via wide-ranging effects on brain function. The results reported here support a recent proposal that sudden infant death syndrome (SIDS) results from a developmental abnormality of medullary serotonergic neurons.