High minichromosome maintenance protein 7 proliferation indices: a powerful predictor of progression in pancreatic neuroendocrine neoplasms without distant metastasis at the time of surgery
High minichromosome maintenance protein 7 proliferation indices: a powerful predictor of progression in pancreatic neuroendocrine neoplasms without distant metastasis at the time of surgery
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DOI：
10.1016/j.humpath.2018.10.027
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发表时间：
2019-03-01
期刊：
影响因子：
3.3
通讯作者：
Chen, Jie
中科院分区：
文献类型：
--
作者：
Ban, Xinchao;Yan, Jie;Chen, Jie
胰腺神经内分泌肿瘤（PanNENs）的临床过程是不可预测的，从惰性到高度恶性不等。没有免疫组化标记物可用于可靠预测早期PanNEN的生物学行为。微小染色体维持蛋白7（MCM 7）是细胞增殖的一个强有力的标志物。MCM 7的表达是否与PanNEN进展的风险有关仍不清楚。我们评估了156例PanNEN的临床表现，包括分期、分级、Ki-67指数、MCM 7指数和其他病理特征。高MCM 7指数与较大的肿瘤大小显著相关（P
Pancreatic neuroendocrine neoplasms (PanNENs) have an unpredictable clinical course that varies from indolent to highly malignant. No immunohistochemical markers are available for reliable prediction of the biological behavior of early stage PanNENs. Minichromosome maintenance protein 7 (MCM7) is a putative powerful marker of cell proliferation. Whether the expression of MCM7 is related to the risk of PanNENs progression remains unclear. We assessed the clinical behavior of 156 PanNENs with respect to stage, grade, Ki-67 index, MCM7 index, and other pathologic features. A high MCM7 index was significantly associated with larger tumor size (P