Behavioral evidence of thermal hyperalgesia in non-obese diabetic mice with and without insulin-dependent diabetes.
Behavioral evidence of thermal hyperalgesia in non-obese diabetic mice with and without insulin-dependent diabetes.
复制标题
患有或不患有胰岛素依赖型糖尿病的非肥胖糖尿病小鼠的热痛觉过敏的行为证据。
DOI：
10.1016/0304-3940(95)11532-2
复制
发表时间：
1995
影响因子：
2.5
通讯作者：
Thalhammer,JG
中科院分区：
文献类型：
--
作者：
Davar,G;Waikar,S;Eisenberg,E;Hattori,M;Thalhammer,JG
The non-obese diabetic (NOD) mouse, a model of Type 1 diabetes in humans, has proven useful for the study of genetic, immunologic and epidemiologic aspects of inherited diabetes. Behavioral evidence of hyperalgesia may also be present in the NOD mouse but has not been described. This study examined NOD mice with (NOD+) and without (NOD−) insulin-dependent diabetes, and control strain (ILI) mice for evidence of hyperalgesia to a noxious thermal stimulus. Interestingly, both NOD+ and NOD− mice showed reduced mean hindpaw withdrawal latencies when compared with non-diabetic ILI mice. NOD+ and NOD− mice were also abnormal in their general appearance, activity level, posture, gait and muscle bulk when compared with ILI mice. These findings raise the possibility that hyperalgesia in insulin-dependent NOD mice, or insulin-dependent humans with Type 1 diabetes, may be independent of diabetes and due to a primary disturbance within sensory pathways.
