Animal models of tuberculosis: Lesson learnt.
Animal models of tuberculosis: Lesson learnt.
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DOI：
10.4103/ijmr.ijmr_554_18
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Gupta UD
中科院分区：
文献类型：
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作者：
Singh AK;Gupta UD
结核病 (TB) 仍然是全球传染病中导致死亡的主要原因，其死亡人数比任何其他传染病都多。动物模型已成为模拟人类传染病的关键。豚鼠、小鼠、兔子和非人类灵长类动物等动物挑战模型可以促进结核病研究。由于这些模型之间的抗病性/易感性存在显着差异，因此没有单一模型能够呈现疾病发病机制的所有方面。多种动物菌株、结核分枝杆菌菌株的可用性、感染途径和剂量会影响疾病进展和干预结果。不同的动物模型对药物和疫苗的开发、生物标志物的鉴定、结核病免疫发病机制的理解以及宿主遗传对感染的影响做出了重大贡献。在这篇综述中，讨论了结核病研究中常用的动物模型及其优点和局限性。
Tuberculosis (TB) remains a leading cause of death globally among infectious diseases that has killed more numbers of people than any other infectious diseases. Animal models have become the lynchpin for mimicking human infectious diseases. Research on TB could be facilitated by animal challenge models such as the guinea pig, mice, rabbit and non-human primates. No single model presents all aspects of disease pathogenesis due to considerable differences in disease resistance/susceptibility between these models. Availability of a wide range of animal strains, Mycobacterium tuberculosis strains, route of infection and doses affect the disease progression and intervention outcome. Different animal models have contributed significantly to the drug and vaccine development, identification of biomarkers, understanding of TB immunopathogenesis and host genetic influence on infection. In this review, the commonly used animal models in TB research are discussed along with their advantages and limitations.