An Integrated Visualization and Basic Molecular Modeling Laboratory for First-Year Undergraduate Medicinal Chemistry
An Integrated Visualization and Basic Molecular Modeling Laboratory for First-Year Undergraduate Medicinal Chemistry
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DOI：
10.1021/ed400486d
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发表时间：
2014-06-01
影响因子：
3
通讯作者：
Hayes, Joseph M.
中科院分区：
文献类型：
--
作者：
Hayes, Joseph M.
一个三维模型可视化和基本的分子建模实验室适合一年级本科生学习介绍药物化学。2小时的实践是嵌入在药物设计，靶向药物相互作用，酶，受体，核酸和基础药代动力学的一系列讲座。作为教学辅助的讲座材料，利用薛定谔软件和大师图形用户界面（GUI）的生物大分子的3D模型进行了探索，以提高学生的学习。与会者的反应相当积极。实验的背景和细节被概述，而学生讲义与答案被包括作为支持信息。
A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid to the lecture material, 3D models of biological macromolecules exploiting Schrodinger software and the Maestro graphical user interface (GUI) is explored to enhance student learning. A considerably positive response was received from the participants. Background and details of the laboratory are outlined, while the student handout with answers is included as Supporting Information.