Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma
Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma
复制标题
DOI：
10.1002/bjs.7393
复制
发表时间：
2011-04-01
影响因子：
9.6
通讯作者：
Monden, M.
中科院分区：
文献类型：
--
作者：
Eguchi, S.;Kanematsu, T.;Monden, M.
背景：肝细胞癌（HCC）根治性切除术后的高复发率仍然是一个问题。肝切除术后无复发的长期生存者的特征可能有助于改善HCC的治疗策略。方法：日本全国范围的数据库用于分析20 811例接受肝切除术的HCC患者。结果：肝癌根治性切除术后10年无复发生存率为22.4%。10年后免费。肝癌测量小于5厘米的83.2%，一个单一的病灶存在于91.7%，和一个简单的结节宏观外观被发现在这些患者的73.3%，组织学上，大多数肝癌显示没有血管侵犯或肝内转移。多变量分析显示，肿瘤分化为最强的预测死亡复发HCC在5 years.Conclusion：长期无复发生存是可能的肝切除术后的HCC，特别是在一个单一的病灶测量小于5厘米，一个简单的结节外观和低肿瘤标志物水平的患者。
Background: High recurrence rates after liver resection with curative intent for hepatocellular carcinoma (HCC) remain a problem. The characterization of long-term survivors without recurrence after liver resection may help improve the therapeutic strategy for HCC.Methods: A nationwide Japanese database was used to analyse 20 811 patients with HCC who underwent liver resection with curative intent.Results: The 10-year recurrence-free survival rate after liver resection for HCC with curative intent was 22.4 per cent. Some 281 patients were recurrence-free after more than 10 years. The HCCs measured less than 5 cm in 83.2 per cent, a single lesion was present in 91.7 per cent, and a simple nodular macroscopic appearance was found in 73.3 per cent of these patients; histologically, most HCCs showed no vascular invasion or intrahepatic metastases. Multivariable analysis revealed tumour differentiation as the strongest predictor of death from recurrent HCC within 5 years.Conclusion: Long-term recurrence-free survival is possible after liver resection for HCC, particularly in patients with a single lesion measuring less than 5 cm with a simple nodular appearance and low tumour marker levels.