Mutagenic activities of fecapentaene derivatives in the Ames/Salmonella test system.
Mutagenic activities of fecapentaene derivatives in the Ames/Salmonella test system.
复制标题
艾姆斯/沙门氏菌测试系统中非卡戊烯衍生物的致突变活性。
DOI：
10.1016/0304-3835(88)90072-9
复制
发表时间：
1988
期刊：
影响因子：
9.7
通讯作者：
Reist,EJ
中科院分区：
文献类型：
--
作者：
Peters,JH;Riccio,ES;Stewart,KR;Reist,EJ
在Ames/Salmonellatest体系中，测定了一对自然产生的和几种合成的拉面五烯类化合物的直接致突变活性。我们发现菌株TA100预培养是对自然产生的肥五烯-12(FP-12)最敏感的过程。其天然类似物FP-14和合成异构体cis-FP-12的诱变活性与FP-12相似，每微克化合物可产生1000-2000个TA100回复变种。合成的FP-12和FP-14、MFP-12和MFP-14的甘油部分被甲氧基取代后，其诱变活性始终高于其亲本拉面五烯类化合物(MFP-12的效力约为FP-12的20倍，MFP-14的效力约为FP-14的两倍)。标准大鼠肝脏代谢系统(S9)以剂量依赖的方式降低所有五烯类化合物的活性。
The direct mutagenic activities of a pair of naturally-occurring and several synthetic fecapentaenes were measured in the Ames/Salmonellatest system. We found that strain TA100 with preincubation was the most sensitive procedure for the naturally-occurring fecapentaene-12 (FP-12). Its natural analog, FP-14, and the synthetic isomer, cis-FP-12, yielded similar mutagenic activities to FP-12 in the range of 1000–2000 TA100 revertants per microgram of compound. The synthetic analogs of FP-12 and FP-14, MFP-12 and MFP-14, wherein the glycerol moiety was replaced by methoxy, exhibited consistently higher mutagenic activities than their parent fecapentaenes (MFP-12 was about 20 times more potent than FP-12; MFP-14 was about twice the potency of FP-14). The standard rat liver metabolizing system (S9) reduced the activities of all the fecapentaenes in a dose-related manner.