Circadian rhythm of pain in male mice
Circadian rhythm of pain in male mice
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DOI：
10.1016/s0306-3623(98)00076-7
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发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Sroczynska, I
中科院分区：
文献类型：
--
作者：
Konecka, AM;Sroczynska, I
1. 研究了雄性小鼠在热刺激下疼痛的昼夜节律。采用热板法。反应潜伏期每2小时测量一次，呈正弦节律。在10和20小时观察到最小的潜伏期，在12和4小时观察到最高潜伏期。疼痛敏感性的昼夜变化可能在应激和应激后镇痛以及药物敏感性的许多实验中发挥重要作用。(C) 1998爱思唯尔科学有限公司
1. Circadian rhythm of pain in response to the thermal stimuli was assessed in male mice.2. The hot-plate method was used. Response latencies were measured every 2 hours and showed a sinusoidal rhythm.3. Minimal latencies were observed at 10 and 20 h, the highest were obtained at 12 and 4 hours.4. The circadian changes in pain sensitivity may play an important role in many experiments on stress and post stress analgesia as well as on susceptibility to pharmacological agents. (C) 1998 Elsevier Science Inc.