Cellular aspects of alpha-fetoprotein reexpression in tumors
Cellular aspects of alpha-fetoprotein reexpression in tumors
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DOI：
10.1006/scbi.1998.0084
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发表时间：
1999-04-01
影响因子：
14.5
通讯作者：
Eraiser, TL
中科院分区：
文献类型：
--
作者：
Abelev, GI;Eraiser, TL
本文综述了甲胎蛋白合成在正常发育、肝脏再生、肝癌发生和肿瘤中的细胞基础。本研究试图解释生殖细胞和肝脏肿瘤产生甲胎蛋白的原因是它们起源于正常情况下产生甲胎蛋白的细胞类型。因此，生殖细胞肿瘤中的AFP可以通过畸胎癌中卵黄囊内脏内胚层（YSVE）的发育来解释，因为YSVE是胚胎中AFP合成的第一个位点。下一个产生甲胎蛋白的部位是胚胎性肝母细胞，在肝癌中，只有肝母细胞瘤是产生甲胎蛋白最多的。肝细胞癌（HCC）中甲胎蛋白恢复的原因尚不清楚。根据卵形细胞在HCC起源中的可能作用，以及成熟肝细胞的两种阶段，与AFP的产生相关和不相关的概念，讨论了这个问题。强调了胞外基质在控制肝细胞产磷酸腺苷状态中的重要作用。
The cellular basis of AFP synthesis in normal development, liver regeneration, hepatocarcinogenesis and in tumors is discussed in the review. The attempt is made to interprete the production of AFP by germ cell and liver tumors as a consequence of their origin from the cell types producing AFP in normal conditions. Thus, AFP in germ cell tumors is explained by the development of the yolk sac visceral endoderm (YSVE) in teratocarcinomas, since YSVE is the first site of AFP synthesis in the embryo. The next site of AFP production is embryonal hepatoblast and just hepatoblastomas are the maximal produces of AFP among liver cancers. The reason for AFP resumption in hepatocellular carcinomas (HCC) is not yet clear. This problem is discussed in the light of possible role of oval cells in the HCC origin and the concept of the two stares of the mature hepatocyte, associated and non-associated with AFP production. The crucial rob of extracellular matrix in the control of AFP-producing state of hepatocyte is emphasized.