Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples
Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples
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DOI：
10.1093/jn/nxab156
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发表时间：
2021-06-05
影响因子：
4.2
通讯作者：
O'Brien, Kimberly O.
中科院分区：
文献类型：
--
作者：
Delaney, Katherine M.;Guillet, Ronnie;O'Brien, Kimberly O.
背景：发育中的胎儿需要足够的铁，并产生自己的激素来调节这一过程。Erythroferrone（ERFE）是最近发现的一种铁调节激素，出生时ERFE浓度和铁状态与其他铁调节激素之间的关系需要规范性数据。目的：本研究的目的是描述出生时脐带ERFE浓度，并评估2组新生儿贫血高危新生儿ERFE、铁调节激素和铁状态生物标志物之间的相互关系。脐带血ERFE浓度的测量是在从携带多胞胎（年龄：21-43岁; n = 127）或青少年（年龄：14-19岁; n = 164）的妇女所生的新生儿中收集的现存血清样本中进行的。结果：所有孕30 ~ 42周的新生儿脐血ERFE均为阳性，出生时平均浓度为0.73 ng/mL（95%CI：0.63，0.85 ng/mL）。黑人新生儿的脐带ERFE平均比白色血统新生儿低0.25 ng/mL（P = 0.04）。脐带ERFE与转铁蛋白受体（β：1.17，P < 0.001）、铁蛋白（β：-0.27，P < 0.01）和血红蛋白（Hb）（β：0.04，P < 0.05）显著相关。然而，脐带铁调素和铁调素：促红细胞生成素（EPO）的比例捕获了新生儿铁和血液状态的最大变化（>25%的方差解释）。结论：新生儿出生的青少年和妇女携带多个能够产生ERFE响应新生儿脐带铁状态和红细胞生成的需求。然而，ERFE并没有捕捉到新生儿铁或Hb浓度的显着差异。在这些新生儿中，脐带hepcidin和hepcidin：EPO比例解释了出生时铁状态指标的最大差异。
Background: The developing fetus requires adequate iron and produces its own hormones to regulate this process. Erythroferrone (ERFE) is a recently identified iron regulatory hormone, and normative data on ERFE concentrations and relations between iron status and other iron regulatory hormones at birth are needed.Objectives: The objective of this study was to characterize cord ERFE concentrations at birth and assess interrelations between ERFE, iron regulatory hormones, and iron status biomarkers in 2 cohorts of newborns at higher risk of neonatal anemia.Methods: Umbilical cord ERFE concentrations were measured in extant serum samples collected from neonates born to women carrying multiples (age: 21-43 y; n = 127) or teens (age: 14-19 y; n = 164). Relations between cord blood ERFE and other markers of iron status or erythropoiesis in cord blood were assessed by linear regression and mediation analysis.Results: Cord ERFE was detectable in all newborns delivered between 30 and 42 weeks of gestation, and mean concentration at birth was 0.73 ng/mL (95% CI: 0.63, 0.85 ng/mL). Cord ERFE was on average 0.25 ng/mL lower in newborns of black as opposed to white ancestry (P = 0.04). Cord ERFE was significantly associated with transferrin receptor (beta: 1.17, P < 0.001), ferritin (beta: -0.27, P < 0.01), and hemoglobin (Hb) (beta: 0.04, P < 0.05). However, cord hepcidin and the hepcidin:erythropoietin (EPO) ratio captured the most variance in newborn iron and hematologic status (>25% of variance explained).Conclusions: Neonates born to teens and women carrying multiples were able to produce ERFE in response to neonatal cord iron status and erythropoietic demand. ERFE, however, did not capture significant variance in newborn iron or Hb concentrations. In these newborns, cord hepcidin and the hepcidin:EPO ratio explained the most variance in iron status indicators at birth.