Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review.
Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review.
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DOI：
10.1186/s13071-016-1311-1
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发表时间：
2016-01-27
影响因子：
3.2
通讯作者：
Anderson RM
中科院分区：
文献类型：
--
作者：
Shuford KV;Turner HC;Anderson RM
预防性化疗方案用于控制五种负担最重的被忽视的热带病：土壤传播的蠕虫感染（钩虫、蛔虫和鞭虫）、淋巴丝虫病、血吸虫病、盘尾丝虫病和沙眼。在过去十年中，对非传染性疾病的新的资源承诺使这些方案能够加强其控制工作，并使某些疾病的目标从控制发病率转向阻断传播和消灭。为了成功地消除寄生虫宿主，这些方案无疑需要长期的高覆盖率治疗。然而，必须考虑到，即使覆盖率达到目标人口的可接受比例，覆盖率（接受药物的人）和遵守率（实际消费药物的人）之间也可能存在相当大的差距-这是一个根本性的问题，其重要性可能被低估了。我们对已发表的文献进行了系统回顾，这些文献调查了NTD控制和消除的PCT计划的依从性。检索的数据库包括PubMed/Medline、Web of Knowledge（包括Web of Science）、奥维德和Scopus。收集了关于依从率、不依从原因以及方案和研究之间依从定义和计算的异质性的数据。共纳入112项研究。审查的结果显示，遵守条款和定义之间存在很大的异质性;特定疾病地区和国家的现有研究不平衡;最后，缺乏纵向遵守研究，以适当调查系统性不遵守的作用。报告遵守情况的数据缺乏一致性，可能导致低估或高估一个群体的遵守情况，因此对制定和实现消除目标产生严重影响。重新制定关于遵守定义的准则，同时紧急呼吁对系统性不遵守行为进行纵向研究，应是从控制到消除的方案转变的基本要素。本文的在线版本（doi：10.1186/s13071-016-1311-1）包含补充材料，可供授权用户使用。
Preventive chemotherapy (PCT) programmes are used to control five of the highest burden neglected tropical diseases (NTDs): soil-transmitted helminth infections (hookworm, ascariasis, and trichuriasis), lymphatic filariasis, schistosomiasis, onchocerciasis, and trachoma. Over the past decade, new resource commitments for the NTDs have enabled such programmes to intensify their control efforts, and for some diseases, to shift from goals of morbidity control to the interruption of transmission and elimination. To successfully eliminate the parasite reservoir, these programmes will undoubtedly require prolonged, high treatment coverage. However, it is important to consider that even when coverage levels reach an acceptable proportion of the target population, there may be a considerable gap between coverage (those who receive the drug) and compliance (those who actually consume the drug)—a topic of fundamental and perhaps underestimated importance. We conducted a systematic review of published literature that investigated compliance to PCT programmes for NTD control and elimination. Databases searched included PubMed/Medline, Web of Knowledge (including Web of Science), OVID, and Scopus. Data were collected on compliance rates, reasons for non-compliance, as well as the heterogeneity of compliance definitions and calculations across programmes and studies. A total of 112 studies were selected for inclusion. The findings of the review revealed substantial heterogeneity across compliance terms and definitions; an imbalance of available studies for particular disease areas and countries; and finally, a lack of longitudinal compliance studies to properly investigate the role of systematic non-compliance. The lack of consistency among reporting of compliance data can result in under- or over-estimating compliance in a population, and therefore has serious implications for setting and reaching elimination targets. Reframing of the guidelines on compliance definitions coupled with an urgent call for longitudinal research in systematic non-compliance should be essential elements in the programmatic shift from control to elimination. The online version of this article (doi:10.1186/s13071-016-1311-1) contains supplementary material, which is available to authorized users.