Effects of caffeine and maltodextrin mouth rinsing on P300, brain imaging, and cognitive performance
Effects of caffeine and maltodextrin mouth rinsing on P300, brain imaging, and cognitive performance
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DOI：
10.1152/japplphysiol.01050.2014
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发表时间：
2015-03-15
影响因子：
3.3
通讯作者：
Meeusen, R.
中科院分区：
文献类型：
--
作者：
De Pauw, K.;Roelands, B.;Meeusen, R.
咖啡因(CAF)和麦芽糊精(MALT)含漱液(MR)可提高运动能力。目前的实验旨在确定CAF和MALT MR对认知表现和大脑活动的影响。10名健康男性受试者(年龄27+/-3岁)完成了三项实验。每个实验包括四个Stroop任务：两个熟悉任务，以及一个MR周期之前和之后的一个任务。评估简单、一致和不一致刺激的反应时间(以毫秒为单位)和准确度(百分比)。在整个实验过程中，脑电图仪被用来记录大脑活动。P300的波幅和潜伏期是在MR检查前后的Stroop任务中测定的。受试者接受随机、双盲、交叉设计的MR治疗，包括CAF(0.3g/25ml)、麦芽(1.6g/25ml)或安慰剂(PLAC)。在MR期间，应用标准化的脑成像技术低分辨率脑电磁层析成像。基于幅度的推断表明，与PLAC MR相比，CAF MR可能是微不足道的(63.5%)，可能是有益的(36.4%)，而与MALT MR相比，可能有利于对不一致刺激的反应时间(61.6%)。此外，眼眶前额叶和背外侧前额叶皮质仅在CAF MR期间被激活，这可能解释了可能对反应时间有利的影响。MALT MR只增加了眼眶前额叶皮质内的大脑活动。然而，这种大脑激活并没有改变反应时间。此外，在不同条件下，刺激反应的准确性没有显著差异。总而言之，只有CAF MR可能对反应时产生有益的影响，这是由于随后激活了眶前叶和背外侧前额叶皮质。
Caffeine (CAF) and maltodextrin (MALT) mouth rinses (MR) improve exercise performance. The current experiment aims to determine the effect of CAF and MALT MR on cognitive performance and brain activity. Ten healthy male subjects (age 27 +/- 3 yr) completed three experimental trials. Each trial included four Stroop tasks: two familiarization tasks, and one task before and one task after an MR period. The reaction time (in milliseconds) and accuracy (percent) of simple, congruent, and incongruent stimuli were assessed. Electroencephalography was applied throughout the experiment to record brain activity. The amplitudes and latencies of the P300 were determined during the Stroop tasks before and after the MR period. Subjects received MR with CAF (0.3 g/25 ml), MALT (1.6 g/25 ml), or placebo (PLAC) in a randomized, double-blind, crossover design. During MR, the brain imaging technique standardized low-resolution brain electromagnetic tomography was applied. Magnitude-based inferences showed that CAF MR is likely trivial (63.5%) and likely beneficial (36.4%) compared with PLAC MR, and compared with MALT MR likely beneficial to reaction time on incongruent stimuli (61.6%). Additionally, both the orbitofrontal and dorsolateral prefrontal cortex were activated only during CAF MR, potentially explaining the likely beneficial effect on reaction times. MALT MR increased brain activity only within the orbitofrontal cortex. However, this brain activation did not alter the reaction time. Furthermore, no significant differences in the accuracy of stimuli responses were observed between conditions. In conclusion, only CAF MR exerted a likely beneficial effect on reaction time due to the subsequent activation of both the orbitofrontal and dorsolateral prefrontal cortexes.