Micellar nanocontainers distribute to defined cytoplasmic organelles
Micellar nanocontainers distribute to defined cytoplasmic organelles
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DOI：
10.1126/science.1078192
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发表时间：
2003-04-25
期刊：
影响因子：
56.9
通讯作者：
Maysinger, D
中科院分区：
文献类型：
--
作者：
Savic, R;Luo, LB;Maysinger, D
嵌段共聚物胶束是一种水溶性的生物相容性纳米容器，具有很大的疏水药物释放潜力。了解它们的细胞分布对于在亚细胞水平实现药物的选择性递送是至关重要的。三重标记的共聚焦显微镜在活细胞中发现胶束在几个细胞质细胞器，包括线粒体，但不是在细胞核中的本地化。此外，胶束改变细胞分布并增加递送至细胞的药剂的量。因此，这些胶束可能是值得探索的潜力，选择性地将药物输送到指定的亚细胞靶点。
Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver drugs to specified subcellular targets.