Propofol reduces early post-operative pain after gynecological laparoscopy
Propofol reduces early post-operative pain after gynecological laparoscopy
复制标题
异丙酚可减轻妇科腹腔镜术后早期疼痛
DOI：
10.1111/j.1399-6576.2011.02603.x
复制
发表时间：
2012-03-01
影响因子：
2.1
通讯作者：
Tian, Y. K.
中科院分区：
文献类型：
--
作者：
Li, M.;Mei, W.;Tian, Y. K.
背景：有证据表明异丙酚可以减轻术后疼痛。然而，关于丙泊酚的镇痛作用的结果不一致。因此，我们假设，丙泊酚减少急性疼痛，如果混淆因素，如阿片类药物是avoided.Methods：在这个前瞻性的，随机的，受试者和评估者盲，平行组，头对头比较研究，90美国麻醉医师协会I或II女性进行择期腹腔镜手术随机接受丙泊酚为基础的（PR），或七氟烷为基础的（SR），或七氟烷丙泊酚为基础的麻醉（SPR）。术后0.5 h通过数字评定量表评估静息时疼痛评分是主要结局。次要结局包括术后1和24 h疼痛评分、术后麻醉监护室（PACU）停留时间、术后恶心呕吐发生率、寒战发生率和术后24 h内的术后恢复质量评分（QoR-40）。PR组术后0.5 h的疼痛评分低于SR组（0.7 +/- 1.4 vs. 2.1 +/- 1.8; P = 0.010）或SPR组（0.7 +/- 1.4 vs. 2.1 +/- 2.2; P = 0.008）。与SR组（21.8 +/- 5.7 vs. 26.2 +/- 6.9; P = 0.050）或SPR组（21.8 +/- 5.7 vs. 27.8 +/- 8.9; P = 0.005）相比，PR组的PACU停留时间也更短。术中脑电双频指数值，血流动力学值和术后QoR-40评分没有显着差异three groups.Conclusions：异丙酚麻醉与手术后0.5和1小时的疼痛显着减少妇科腹腔镜手术与计划的阿片类药物术后镇痛的患者。
Background: There is some evidence that propofol may reduce post-operative pain. However, the results on the analgesic effects of propofol are inconsistent. Thus, we hypothesized that propofol reduces acute pain if confounding factors like opioids are avoided.Methods: In this prospective, randomized, subject-and assessor-blind, parallel-group, head-to-head comparative study, 90 American Society of Anesthesiologists I or II females underwent elective laparoscopies were randomized to receive either propofol-based (PR), or sevoflurane-based (SR), or sevofluranepropofol- based anesthesia (SPR). Pain score at rest assessed by a numerical rating scale at 0.5 h after surgery was the primary outcome. The secondary outcomes included pain score at 1 and 24 h post-operatively, duration of post-anesthesia care units stay (PACU), incidence of post-operative nausea and vomiting, incidence of shivering, and post-operative quality of recovery score (QoR-40) within the first 24 h post-operatively.Results: No patients received rescue analgesia. The pain score at 0.5 h post-operatively was less in group PR when compared with group SR (0.7 +/- 1.4 vs. 2.1 +/- 1.8; P = 0.010) or group SPR (0.7 +/- 1.4 vs. 2.1 +/- 2.2; P = 0.008). Group PR was also associated with shorter PACU stay than group SR (21.8 +/- 5.7 vs. 26.2 +/- 6.9; P = 0.050) or group SPR (21.8 +/- 5.7 vs. 27.8 +/- 8.9; P = 0.005). Intraoperative bispectral index values, hemodynamic values and post-operative QoR-40 scores did not differ among the three groups.Conclusions: Propofol anesthesia was associated with significantly less pain at 0.5 and 1 h after surgery in patients undergoing gynecological laparoscopies with planned opioid-free post-operative analgesia.