Cross-sectional assessment reveals high diabetes prevalence among newly-diagnosed tuberculosis cases
Cross-sectional assessment reveals high diabetes prevalence among newly-diagnosed tuberculosis cases
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DOI：
10.2471/blt.10.085738
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发表时间：
2011-05-01
期刊：
影响因子：
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通讯作者：
Fisher-Hoch, Susan P
中科院分区：
文献类型：
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作者：
Restrepo, Blanca I;Camerlin, Aulasa J;Fisher-Hoch, Susan P
目的 评估临床确诊的糖尿病对两种疾病流行的社区中结核病 (TB) 发病率的影响，以此确定糖尿病患者中结核病预防的机会。 方法 这是一项前瞻性研究，对德克萨斯州墨西哥边境结核病诊所的 20 岁结核病患者进行了糖尿病检测。由糖尿病引起的结核病风险是根据相应成年人口的统计数据估计的。研究结果德克萨斯州结核病患者中糖尿病的患病率为 39%，墨西哥为 36%。在研究的结核病病例中，糖尿病占 25%，而人类免疫缺陷病毒 (HIV) 感染占 5% 或更少。在结核病患者中，在这项研究之前意识到自己患有糖尿病的墨西哥人比德克萨斯人要少（分别为 4% 和 19%）。男性也比女性更少意识到自己患有糖尿病（P=0.03）。在研究之前知道自己患有糖尿病的患者在被诊断为结核病之前平均有 8 年的病史。结论 糖尿病患者比非糖尿病患者感染结核病的风险更高。将全球结核病和糖尿病控制计划结合起来将有助于糖尿病患者的结核病预防，并增加了解自身病情的糖尿病患者数量，特别是男性。这样的策略将有助于更早地发现病例并改善结核病和糖尿病的管理。
Objective To estimate the contribution of clinically-confirmed diabetes mellitus to tuberculosis (TB) rates in communities where both diseases are prevalent as a way to identify opportunities for TB prevention among diabetic patients.Methods This is a prospective study in which TB patients 20 years old at TB clinics in the Texas Mexico border were tested for diabetes. The risk of tuberculosis attributable to diabetes was estimated from statistics for the corresponding adult population.Findings The prevalence of diabetes among TB patients was 39% in Texas and 36% in Mexico. Diabetes contributed 25% of the TB cases studied, whereas human immunodeficiency virus (HIV) infection contributed 5% or fewer. Among TB patients, fewer Mexicans than Texans were aware that they had diabetes before this study (4% and 19%, respectively). Men were also less frequently aware than women that they had diabetes (P=0.03). Patients who knew that they had diabetes before the study had an 8-year history of the disease, on average, before being diagnosed with TB.Conclusion Patients with diabetes are at higher risk of contracting TB than non-diabetic patients. Integrating TB and diabetes control programmes worldwide would facilitate TB prevention among diabetes patients and increase the number of diabetics who learn of their condition, particularly among males. Such a strategy would lead to earlier case detection and improve the management of both TB and diabetes.