Clinical Utility of Dual-Energy CT for Evaluation of Tophaceous Gout
Clinical Utility of Dual-Energy CT for Evaluation of Tophaceous Gout
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DOI：
10.1148/rg.315115510
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发表时间：
2011-09-01
期刊：
影响因子：
5.5
通讯作者：
Kransdorf, Mark J.
中科院分区：
文献类型：
--
作者：
Desai, Madhura A.;Peterson, Jeffrey J.;Kransdorf, Mark J.
虽然诊断痛风一般是简单的，非典型疾病可能会提出一个挑战，如果它与不寻常的症状或网站，不一致的血清尿酸水平，或痛风的拟态。双能量计算机断层扫描（CT）可以通过使用特定的衰减特征来区分尿酸盐晶体和钙，这可能有助于诊断痛风。在已知痛风石性痛风患者中，双能CT可用于亚临床痛风石的连续体积定量，以评估对治疗的反应。鉴于双能CT在具有挑战性的病例中的实用性及其在痛风石样痛风患者中提供客观结局测量的能力，双能CT有望成为痛风诊断和管理中独特的临床相关模式。
Although diagnosing gout generally is straightforward, atypical disease may present a challenge if it is associated with unusual symptoms or sites, discordant serum urate level, or mimics of gout. Dual-energy computed tomography (CT) may be used to differentiate urate crystals from calcium by using specific attenuation characteristics, which may help diagnose gout. In patients with known tophaceous gout, dual-energy CT may be used for serial volumetric quantification of subclinical tophi to evaluate response to treatment. Given the utility of dual-energy CT in challenging cases and its ability to provide an objective outcomes measure in patients with tophaceous gout, dual-energy CT promises to be a unique and clinically relevant modality in the diagnosis and management of gout.