Entamoeba histolytica activates host cell caspases during contact-dependent cell killing.
Entamoeba histolytica activates host cell caspases during contact-dependent cell killing.
复制标题
溶组织内阿米巴在接触依赖性细胞杀伤过程中激活宿主细胞半胱天冬酶。
DOI：
10.1007/3-540-27320-4_8
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发表时间：
2005
影响因子：
--
通讯作者：
Petri,WA
中科院分区：
文献类型：
--
作者：
Boettner,DR;Petri,WA
溶组织内阿米巴是一种人体肠道寄生虫，可引起阿米巴结肠炎和肝脓肿。宿主组织通过三步过程受损，包括粘附、接触依赖性细胞溶解和吞噬作用。这三个过程都有助于这种寄生虫的致病性。粘附由Gal/GalNAc粘附凝集素提供。宿主细胞以接触依赖性方式裂解。有证据表明，这种接触依赖性杀伤涉及宿主细胞凋亡机制的诱导。然后可以发生吞噬作用，与后生动物凋亡清除一致。
Entamoeba histolyticais a human intestinal parasite that causes amoebic colitis as well as liver abscesses. Host tissues are damaged through a three-step process involving adherence, contact-dependent cytolysis, and phagocytosis. These three processes all contribute to the pathogenicity of this parasite. Adherence is provided by the Gal/GalNAc adherence lectin. Host cells are lysed in a contact-dependent fashion. There is evidence that suggests that this contact-dependent killing involves the induction of the host cell’s apoptotic machinery. Phagocytosis can then occur, consistent with metazoan apoptotic clearance.