Cadmium, follicle-stimulating hormone, and effects on bone in women age 42-60 years, NHANES III
Cadmium, follicle-stimulating hormone, and effects on bone in women age 42-60 years, NHANES III
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DOI：
10.1016/j.envres.2009.09.012
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发表时间：
2010-01-01
影响因子：
8.3
通讯作者：
Kovach, John S.
中科院分区：
文献类型：
--
作者：
Gallagher, Carolyn M.;Moonga, Baljit S.;Kovach, John S.
背景资料：环境镉的身体负荷增加与中老年妇女骨密度（BMD）降低和骨质疏松症的风险增加有关，据报道，中年妇女的促卵泡激素（FSH）与BMD呈负相关;然而，镉和FSH之间的关系是不确定的，并且还没有在单一人群中分析每种与骨丢失的关联。目的：本研究的目的是评估肌酐调整的尿镉（UCd）和FSH水平之间的关系，方法：资料来源于19881994年第三次全国健康体检与营养调查（NHANES III）。评价的结果包括血清FSH水平、双能X线骨密度仪测量的股骨骨密度和基于国际标准的股骨BMD临界值指示的骨质疏松症。使用多元回归分析尿镉水平与这些结果的相关性，以及FSH水平与骨效应的相关性。结果：在高BMI围绝经期妇女中，UCd与血清FSH升高相关（n = 642; β = 0.45; p <0.01），UCd与血清FSH升高相关（p <0.05）。
Background: Increased body burden of environmental cadmium has been associated with greater risk of decreased bone mineral density (BMD) and osteoporosis in middle-aged and older women, and an inverse relationship has been reported between follicle-stimulating hormone (FSH) and BMD in middle-aged women; however, the relationships between cadmium and FSH are uncertain, and the associations of each with bone loss have not been analyzed in a single population.Objectives: The objective of this study was to evaluate the associations between creatinine-adjusted urinary cadmium (UCd) and FSH levels, and the associations between UCd and FSH with BMD and osteoporosis, in postmenopausal and perimenopausal women aged 42-60 years.Methods: Data were obtained from the Third National Health Examination and Nutrition Survey, 19881994 (NHANES III). Outcomes evaluated were serum FSH levels, femoral bone mineral density measured by dual energy X-ray absorptiometry, and osteoporosis indicated by femoral BMD cutoffs based on the international standard. Urinary cadmium levels were analyzed for association with these outcomes, and FSH levels analyzed for association with bone effects, using multiple regression. Subset analysis was conducted by a dichotomous measure of body mass index (BMI) to proxy higher and lower adipose-synthesized estrogen effects.Results: UCd was associated with increased serum FSH in perimenopausal women with high BMI (n = 642; beta = 0.45; p