Biochemical Computation for Spine Structural Plasticity.
Biochemical Computation for Spine Structural Plasticity.
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DOI：
10.1016/j.neuron.2015.05.043
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发表时间：
2015-07-01
期刊：
影响因子：
16.2
通讯作者：
Yasuda R
中科院分区：
文献类型：
--
作者：
Nishiyama J;Yasuda R
树棘的结构可塑性被认为对于各种形式的突触可塑性、学习和记忆至关重要。这一过程是由一个复杂的信号网络介导的，该网络由许多种类的分子组成。此外，由于树突状分支和棘的独特形态的几何限制，以复杂的方式调节生化信号的时空动力学。光学技术的最新进展，使探索的时空方面的信号调节的脊椎和树突，并提供了许多见解的生化计算的原则，脊柱结构的可塑性。
The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity, learning and memory. The process is mediated by a complex signaling network consisting of numerous species of molecules. Furthermore, the spatiotemporal dynamics of the biochemical signaling is regulated in a complicated manner due to geometrical restrictions from the unique morphology of the dendritic branches and spines. Recent advances in optical techniques have enabled the exploration of the spatiotemporal aspects of the signal regulations in spines and dendrites and have provided many insights into the principle of the biochemical computation that underlies spine structural plasticity.