Cytokine inhibition preserves renal hemodynamic function following mesangial cell immune injury.

Cytokine inhibition preserves renal hemodynamic function following mesangial cell immune injury.
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DOI：
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发表时间：
1996-08
期刊：
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
影响因子：
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通讯作者：
C. Pan;B. Bresnahan;C. Albrightson;D. Griswold;E. Lianos
C. Pan;B. Bresnahan;C. Albrightson;D. Griswold;E. Lianos
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其他
文献类型：
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作者：
C. Pan;B. Bresnahan;C. Albrightson;D. Griswold;E. Lianos

文献摘要

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BACKGROUND We assessed the effect of a cytokine inhibitor, compound SKF 86002 (a bicyclic imidazole), on changes in renal hemodynamics (renal blood flow and glomerular filtration rate) that occur acutely following immune injury of glomerular mesangial cells. METHODS Injury was induced in Munich-Wistar rats by the administration of a monoclonal antibody against the mesangial cell membrane antigen Thy 1.1. An acute drop in renal blood flow (RBF) and glomerular filtration rate (GFR) occurred within one hour of injury. RESULTS Pretreatment of animals with the cytokine inhibitor SKF 86002 prevented this drop. SKF 86002 had no effect on glomerular synthesis of vasoconstrictor eicosanoids. CONCLUSIONS The observations indicate that in mesangial cell immune injury, cytokines mediate renal hemodynamic impairment.