The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats.
The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats.
复制标题
袖状胃切除术对Goto-Kakizaki大鼠葡萄糖代谢和胰高血糖素样肽1的影响
DOI：
10.1155/2018/1082561
复制
发表时间：
2018
影响因子：
4.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Li L;Wang X;Bai L;Yu H;Huang Z;Huang A;Luo Y;Wang J
目的探讨袖状胃切除术（SG）对Goto-Kakizaki（GK）大鼠糖代谢及胰高血糖素样肽1（GLP-1）的影响。方法将GK大鼠随机分为SG组、SG配对喂养加假手术组（PF sham）和不手术组（control）。比较食物摄入、体重、血糖、GLP-1和胰岛素水平以及空肠和回肠中GLP-1表达。结果SG组大鼠术后进食量、体重、空腹血糖均低于对照组（P < 0.05）。SG能显著改善糖耐量和胰岛素耐量（P < 0.05）。在口服葡萄糖耐量试验（OGTT）中，SG大鼠血浆GLP-1水平高于对照组和PF假手术组（P < 0.05）。在给予exendin（9-39）后，SG大鼠的血糖水平以基线百分比表示高于对照大鼠（P < 0.05）。SG组大鼠空肠和回肠GLP-1表达水平高于PF假手术组和对照组（P < 0.05）。结论SG对糖代谢的改善与GLP-1的分泌增加有关。SG通过增加空肠和/或回肠粘膜中的GLP-1表达，促进血浆GLP-1水平升高。
Purpose To investigate the effects of sleeve gastrectomy (SG) on glucose metabolism and changes in glucagon-like peptide 1 (GLP-1) in Goto-Kakizaki (GK) rats. Methods GK rats were randomly assigned to one of three groups: SG, SG pair-fed plus sham surgery (PF-sham), and ad libitum-fed no surgery (control). Food intake, body weight, blood glucose, GLP-1 and insulin levels, and GLP-1 expression in the jejunum and ileum were compared. Results The SG rats exhibited lower postoperative food intake, body weight, and fasting glucose than did the control rats (P < 0.05). SG significantly improved glucose and insulin tolerance (P < 0.05). Plasma GLP-1 levels were higher in SG rats than in control or PF-sham rats in the oral glucose tolerance test (OGTT) (P < 0.05). Blood glucose levels expressed as a percentage of baseline were higher in SG rats than in control rats after exendin (9-39) administration (P < 0.05). The levels of GLP-1 expression in the jejunum and ileum were higher in SG rats than in PF-sham and control rats (P < 0.05). Conclusions Improvement of glucose metabolism by SG was associated with increased GLP-1 secretion. SG contributes to an increase in plasma GLP-1 levels via increased GLP-1 expression in the mucosa of the jejunum and/or ileum.
登录
查看更多内容
影响因子：
2.9
作者：
Rizzello, Mario;Abbatini, Francesca;Basso, Nicola
通讯作者：
Basso, Nicola
影响因子：
9
作者：
Meirelles K;Ahmed T;Culnan DM;Lynch CJ;Lang CH;Cooney RN
通讯作者：
Cooney RN
影响因子：
2.9
作者：
Regan, JP;Inabnet, WB;Pomp, A
通讯作者：
Pomp, A
影响因子：
3.8
作者：
Patriti, Alberto;Aisa, Maria Cristina;Donini, Annibale
通讯作者：
Donini, Annibale
影响因子：
3.2
作者：
Kindel, Tammy L.;Yoder, Stephanie M.;Tso, Patrick
通讯作者：
Tso, Patrick