4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.
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4,5-二取代顺式吡咯烷酮作为 II 型 17β-羟基类固醇脱氢酶的抑制剂。
DOI：
10.1016/j.bmcl.2006.06.041
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发表时间：
2006
影响因子：
2.7
通讯作者：
Zhonghua Zhang
中科院分区：
文献类型：
--
作者：
Jill E. Wood;C. Bagi;Christiana Akuche;Antonietta Bacchiocchi;J. Baryza;Marie;C. Brennan;A. Campbell;Soongyu Choi;James H. Cook;Patricia Conrad;Brian R. Dixon;P. Ehrlich;Todd Gane;D. Gunn;Ted Joe;Jeffrey S. Johnson;Jerold J. Jordan;R. Kramss;Peiying Liu;Joan Levy;D. Lowe;Ian A. Mcalexander;R. Natero;A. Redman;W. Scott;C. Town;Ming Wang;Yamin Wang;Zhonghua Zhang
研究了一系列4，5-二取代顺式吡咯烷酮类化合物作为17β-HSD II的抑制剂治疗骨质疏松症。给出了几种化合物的生化数据。化合物42被选为主要候选化合物。
A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.