Effect of injection techniques on the rate of local adverse events in patients implanted with nonanimal hyaluronic acid gel dermal fillers
Effect of injection techniques on the rate of local adverse events in patients implanted with nonanimal hyaluronic acid gel dermal fillers
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DOI：
10.1111/j.1524-4725.2008.34251.x
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发表时间：
2008-06-01
影响因子：
2.4
通讯作者：
Kane, Michael A. C.
中科院分区：
文献类型：
--
作者：
Glogau, Richard G.;Kane, Michael A. C.
背景与皮肤填充物有关的一个问题是，治疗后局部不良事件的发生率和变异性是否与注射技术和针头创伤或内在化学成分有关。一项对照研究纳入了283名患者，这些患者被随机分配接受鼻唇沟和口腔连合的面中部体积矫正，使用非动物稳定的透明质酸（NASHA）凝胶填充剂Restylane或Perlane（Medicis Pharmaceutical Corp.）。收集多个注射技术变量的数据，以评估不良事件。扇形针头使用、快速注射、快速流速和更高体积）增加了局部不良事件的发生率。增加表皮损伤或皮下暴露的注射技术（例如，多次穿刺或深皮下注射）对不良事件没有影响。此外，单次注射校正，注射深度，和注射的NASHA产品对局部不良事件没有影响。结论：本研究中使用的NASHA凝胶填充剂注射后的局部不良事件与调查技术有关，而不是在NASHA代理的内在特性的差异。
BACKGROUND One question associated with dermal fillers is whether the rate and variability of local adverse events following treatment are related to injection technique and needle trauma or to the intrinsic chemical composition.OBJECTIVE The objective was to determine if there is a relationship between dermal filler injection technique and the incidence of local adverse events.METHODS AND MATERIALS A prospective, blinded, controlled study enrolled 283 patients who were randomized to receive midface volume correction of the nasolabial folds and oral commissures with the nonanimal-stabilized hyaluronic acid (NASHA) gel filler Restylane or Perlane (Medicis Pharmaceutical Corp.). Data were collected on multiple injection technique variables to assess adverse events.RESULTS Injection techniques that increase the dissection of the subepidermal plane (e.g., fanlike needle use, rapid injection, rapid flow rates, and higher volumes) increased the incidence of local adverse events. Injection techniques that increase epidermal damage or subcutaneous exposure (e.g., multiple punctures or deep subcutaneous injection) had no effect on adverse events. Furthermore, single injection correction, depth of injection, and NASHA product injected had no effect on local adverse events.CONCLUSIONS Local adverse events following injection with the NASHA gel fillers used in this study were related to investigator technique and not to differences in the intrinsic properties of the NASHA agents.