Current status of pig heart xenotransplantation.
Current status of pig heart xenotransplantation.
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DOI：
10.1016/j.ijsu.2015.08.038
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
McGregor CGA
中科院分区：
文献类型：
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作者：
Mohiuddin MM;Reichart B;Byrne GW;McGregor CGA
近年来，使用临床相关的大型动物猪-狒狒模型在理解和克服心脏异种移植排斥反应方面取得了重大进展。这一进展是基于改进的免疫抑制，其实现了对B淋巴细胞和可能更新的供体遗传学的更有效的调节。这些改善提高了异位心脏异种移植物的存活率，从几周提高到2年以上，胸内异位心脏异种移植物存活率为50天，原位存活率为57天。这一令人鼓舞的进展重新点燃了人们对异种移植研究的兴趣，并重新关注临床前原位心脏异种移植。
Significant progress in understanding and overcoming cardiac xenograft rejection using a clinically relevant large animal pig-to-baboon model has accelerated in recent years. This advancement is based on improved immune suppression, which attained more effective regulation of B lymphocytes and possibly newer donor genetics. These improvements have enhanced heterotopic cardiac xenograft survival from a few weeks to over 2 years, achieved intrathoracic heterotopic cardiac xenograft survival of 50 days and orthotopic survival of 57 days. This encouraging progress has rekindled interest in xenotransplantation research and refocused efforts on preclinical orthotopic cardiac xenotransplantation.