A physiological change in the homotopic cortex following left posterior temporal lobe infarction
A physiological change in the homotopic cortex following left posterior temporal lobe infarction
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DOI：
10.1002/ana.10181
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发表时间：
2002-05-01
影响因子：
11.2
通讯作者：
Wise, R
中科院分区：
文献类型：
--
作者：
Leff, A;Crinion, J;Wise, R
我们研究了正常受试者和失语症患者的大脑活动（通过正电子发射断层扫描测量）和语速之间的关系，这些患者以与正常言语相同的速度聆听单音节单词。通过测量正常受试者颞叶皮层中个体活动词率反应的回归斜率，我们发现了颞上沟后部的功能不对称性。左侧的响应更大（更陡）。使用相同的研究设计，我们发现在左后颞皮质梗塞后恢复单词听觉理解能力的患者的右后颞上沟中存在更陡峭的活动词率反应。这种反应与在正常受试者和一组左半球梗塞但后颞叶皮层未受损伤的患者中观察到的反应显着不同。结果表明，后颞叶梗塞后对侧同伦皮层的生理反应发生了变化。
We investigated the relationship between cerebral activity (measured with positron emission tomography) and word rate in normal subjects and aphasic patients listening to monosyllabic words at rates up to those encountered in normal speech. By measuring the slope of the regression of the individual activity-word rate responses in the temporal cortex in normal subjects, we identified a functional asymmetry in the posterior superior temporal sulcus. The response was greater (steeper) on the left. Using the same study design, we identified a steeper activity-word rate response in the right posterior superior temporal sulcus of patients who had recovered single-word auditory comprehension after infarction of the left posterior temporal cortex. This response was significantly different from that observed in both normal subjects and a group of patients with left hemisphere infarcts that spared the posterior temporal cortex. The results demonstrated a change in physiological responsiveness in the contralateral homotopic cortex after posterior temporal infarction.