Selective rapid eye movement sleep deprivation impairs the maintenance of long-term potentiation in the rat hippocampus
Selective rapid eye movement sleep deprivation impairs the maintenance of long-term potentiation in the rat hippocampus
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DOI：
10.1111/j.1460-9568.2006.04874.x
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Nakamura, Shoji
中科院分区：
文献类型：
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作者：
Ishikawa, Akinori;Kanayama, Yasuyo;Nakamura, Shoji
众所周知，快速眼动(REM)睡眠剥夺(RSD)会损害学习和记忆。以往的研究表明，RSD可引起海马长时程增强(LTP)的损伤。在大多数这些研究中，RSD是在LTP诱导之前建立的。在这项工作中，我们重点研究了LTP诱导后的RSD。我们研究了齿状回LTP诱导后24-48h的RSD对LTP维持的影响，以及48h后REM的反弹是否影响LTP。RSD大鼠通过用刷子抚摸背部来剥夺REM睡眠，而对照组大鼠被允许自由睡眠。另一对照组大鼠在相同条件下的非快速眼动睡眠(NRS)中被唤醒(NRS组)。与对照组和NRS组相比，剥夺REM的大鼠在24小时的记录时间内表现出更快的群体峰电位幅度的衰减。在RSD后48h，RSD释放前和释放后4h的群体峰电位幅度没有差异。这些结果表明，LTP诱导后齿状回的REM睡眠在LTP维持中起重要作用，而REM反弹不能恢复RSD所致的LTP损伤。
Rapid eye movement (REM) sleep deprivation (RSD) is known to impair learning and memory. Previous studies have demonstrated that RSD induces an impairment of hippocampal long-term potentiation (LTP). In most of these studies, RSD was set up prior to LTP induction. In this work, we focused on RSD after LTP induction. We investigated the effect of RSD for 24-48 h after induction of LTP in the dentate gyrus on LTP maintenance and whether a REM rebound after 48 h RSD affected LTP. RSD rats were deprived of REM sleep by stroking their backs using a brush, whereas control rats were allowed to sleep freely. Another control group of rats was awoken during non-REM sleep (NRS) under the same conditions (NRS group). REM-deprived rats displayed a faster decay of population spike amplitudes compared with the control and NRS groups over a 24-h recording time. After 48 h RSD, there was no difference in the population spike amplitudes before or after 4 h of release from RSD. These results suggest that REM sleep after LTP induction in the dentate gyrus plays an essential role in LTP maintenance, whereas a REM rebound does not restore the RSD-induced impairment of LTP.