Solid-phase synthesis of styryl dyes and their application as amyloid sensors
Solid-phase synthesis of styryl dyes and their application as amyloid sensors
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DOI：
10.1002/anie.200461600
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发表时间：
2004-01-01
影响因子：
16.6
通讯作者：
Chang, YT
中科院分区：
文献类型：
--
作者：
Li, QA;Lee, JS;Chang, YT
组合方法：通过固相化学制备荧光苯乙烯基染料（320种化合物）库。这些染料被筛选用于检测淀粉样蛋白聚集体，这与阿尔茨海默氏症等疾病有关，筛选的320种化合物中有两种，2C40和2E10，显示出作为脑成像剂的前景（见显微镜图像）。（化学方程式）。
The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image).(Chemical equation presented).