Endothelial cell delivery for cardiovascular therapy.
Endothelial cell delivery for cardiovascular therapy.
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DOI：
10.1016/s0169-409x(00)00058-2
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发表时间：
2000-08
影响因子：
16.1
通讯作者：
S. Parikh;E. Edelman;E. Edelman
中科院分区：
文献类型：
--
作者：
S. Parikh;E. Edelman;E. Edelman
阻塞性动脉粥样硬化性血管疾病是世界上最大的公共卫生威胁之一。虽然已经开发了许多治疗方法来对抗血管疾病，但内皮细胞递送已经成为一种独特的治疗方式。在这篇文章中，我们将回顾正常血管的解剖学和完整内皮的生物学，专注于其在血管生物学中的中心地位和对血管对损伤的反应成分的控制，以便更好地理解以细胞为基础的治疗形式的动机。我们讨论的细胞输送心血管治疗将分为手术和介入方法。在将注意力转向内皮细胞种植的血管移植物之前，我们将简要叙述用于外科血管旁路术的人工移植物的发展，其中内皮细胞有效地提供内源性内皮分泌产物的局部递送，以维持外科植入后的假体完整性。将介绍血管移植物和全血管的组织和基因工程的新技术。也将检查经皮介入的方法。我们将评估腔内内皮细胞接种治疗再狭窄和基因治疗方法，以提高内源性再内皮化的结果。最后，我们将研究一些创新的内皮细胞交付，可能导致发展的内皮细胞植入物作为一种新的治疗控制增殖性血管动脉病。
Obstructive atherosclerotic vascular disease stands as one of the greatest public health threats in the world. While a number of therapies have been developed to combat vascular disease, endothelial cell delivery has emerged as a distinct therapeutic modality. In this article, we will review the anatomy of the normal blood vessel and the biology of the intact endothelium, focusing upon its centrality in vascular biology and control over the components of the vascular response to injury so as to understand better the motivation for a cell-based form of therapy. Our discussion of cell delivery for cardiovascular therapy will be divided into surgical and interventional approaches. We will briefly recount the development of artificial grafts for surgical vascular bypass before turning our attention towards endothelial cell seeded vascular grafts, in which endothelial cells effectively provide local delivery of endogenous endothelial secretory products to maintain prosthetic integrity after surgical implantation. New techniques in tissue and genetic engineering of vascular grafts and whole blood vessels will be presented. Methods for percutaneous interventions will be examined as well. We will evaluate results of endoluminal endothelial cell seeding for treatment of restenosis and gene therapy approaches to enhance endogenous re-endothelialization. Finally, we will examine some innovations in endothelial cell delivery that may lead to the development of endothelial cell implants as a novel therapy for controlling proliferative vascular arteriopathy.