Recent Advances in BLV Research.
Recent Advances in BLV Research.
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DOI：
10.3390/v7112929
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发表时间：
2015-11-24
期刊：
影响因子：
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通讯作者：
Willems L
中科院分区：
文献类型：
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作者：
Barez PY;de Brogniez A;Carpentier A;Gazon H;Gillet N;Gutiérrez G;Hamaidia M;Jacques JR;Perike S;Neelature Sriramareddy S;Renotte N;Staumont B;Reichert M;Trono K;Willems L
人类嗜T淋巴细胞病毒（Human T-lymphotropic Virus，HTLV）诱导的发病机制已被提出不同的动物模型：大鼠、转基因和NOD-SCID/γcnull（NOG）小鼠、兔、松鼠猴、狒狒和猕猴。这些系统确实提供了有用的信息，但有内在的局限性，如缺乏疾病相关性，物种特异性或免疫反应不足。另一种基于比较病毒学方法的策略是描述相关病原体的特征并推测可能的共同机制。从这个角度来看，牛白血病病毒（BLV），三角洲逆转录病毒属的另一个成员，是进化相关的HTLV-1。BLV诱导反刍动物淋巴组织增生性疾病，为病毒持续存在的机制、致病的遗传决定因素和潜在的新疗法提供了有用的信息。
Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.