Chromosomal localization of the human apoprotein CI gene and of a polymorphic apoprotein AII gene.
Chromosomal localization of the human apoprotein CI gene and of a polymorphic apoprotein AII gene.
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人类脱辅基蛋白 CI 基因和多态性脱辅基蛋白 AII 基因的染色体定位。
DOI：
10.1016/s0006-291x(84)80368-x
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发表时间：
1984
影响因子：
3.1
通讯作者：
Shows,TB
中科院分区：
文献类型：
--
作者：
Knott,TJ;Eddy,RL;Robertson,ME;Priestley,LM;Scott,J;Shows,TB
人类脱辅基蛋白 (apo) CI 和 apo AII cDNA 探针已用于分析人-小鼠杂交组中人类基因的分离。 apo CI (APOCI) 基因与 19 号染色体分离，apo AII (APOA2) 基因与 1 号染色体分离。使用含有染色体易位的体细胞杂交体将 apo AII 基因定位到 1p21-1qter 区域。 HumanAPOA2 具有限制性内切酶 MspI 的多态性。人类和小鼠1号染色体的比较揭示了一个保守的基因组，包括apo AII、肾素和肽酶基因，并表明APOA2将在人类1号染色体上位于该组的远端。小鼠apo AII基因与调节HDL结构的基因密切相关。类似的 HDL 调节基因可能会在人类 APOA2 附近找到。
Human apoprotein(apo) CI and apo AII cDNA probes have been used to analyze the segregation of the human genes in panels of human-mouse hybrids. The apo CI (APOCI) gene segregates with chromosome 19 and the apo AII (APOA2) gene with chromosome 1. Somatic cell hybrids containing chromosome translocations were used to map the apo AII gene to the 1p21-1qter region. HumanAPOA2is polymorphic for the restriction endonucleaseMspI. Comparison of human and mouse chromosome 1 reveals a conserved group including apo AII, renin and peptidase genes and suggests thatAPOA2will be found distal to this group on human chromosome 1. The mouse apo AII gene is closely linked with genes that regulate HDL structure. Similar HDL regulatory genes will probably be found near humanAPOA2.