THE MICROAEROPHILY AND PHOTOSENSITIVITY OF PROPIONIBACTERIUM-ACNES
THE MICROAEROPHILY AND PHOTOSENSITIVITY OF PROPIONIBACTERIUM-ACNES
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DOI：
10.1111/j.1365-2672.1994.tb04405.x
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发表时间：
1994-11-01
期刊：
影响因子：
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通讯作者：
HOLLAND, KT
中科院分区：
文献类型：
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作者：
GRIBBON, EM;SHOESMITH, JG;HOLLAND, KT
在规定的培养条件下，研究了氧对痤疮丙酸杆菌体外繁殖的影响。这种微生物是居住在人体皮肤皮脂丰富区域的毛囊皮脂腺内的主要细菌。该生物在以葡萄糖为主要碳能量来源的合成培养基中连续培养，在不同的空气饱和浓度和有光和无光条件下生长。稳定状态的连续培养是在非常低的氧张力下在光的存在，并在较高水平的氧时，不照明，培养生物量产量高于那些厌氧培养。细菌细胞在高氧浓度的光存在下失活，因为涉及过量氧和微生物卟啉的光敏反应。
The effect of oxygen on the in vitro propagation of Propionibacterium acnes was investigated under defined culture conditions. This micro-organism is the predominant bacterial resident within the pilosebaceous follicles of sebum-rich areas of human skin. The organism was grown in continuous culture in defined synthetic medium with glucose as the main carbon-energy source at various air saturation concentrations and in the presence and absence of light. Steady state continuous cultures were achieved at very low oxygen tensions in the presence of light, and at higher levels of oxygen when non-illuminated, Culture biomass yields were higher than those of anaerobic cultures. Bacterial cells were inactivated in the presence of light at high oxygen concentrations because of photosensitization reactions involving excess oxygen and microbial porphyrin species.