The effect of gastrointestinal hormones on the gastric microcirculation.
The effect of gastrointestinal hormones on the gastric microcirculation.
复制标题
胃肠激素对胃微循环的影响。
DOI：
10.1016/s0016-5085(76)80451-9
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发表时间：
1976
期刊：
影响因子：
29.4
通讯作者：
Esther Smith
中科院分区：
文献类型：
--
作者：
Paul H. Guth;Esther Smith
本研究的目的是利用体内显微镜技术评估几种胃肠激素对胃粘膜下小动脉的影响。在麻醉猫的腹腔轴注射不同的药物后，测量了40 ~ 90µin直径的粘膜下小动脉的改变。Pentagastrin，胆囊收缩素的八肽，天然分泌素和组胺产生小动脉扩张。只有使用组胺和缩胆素八肽时，这种情况才会发生，其剂量可能被认为是生理上的。合成分泌素没有血管扩张活性，表明天然分泌素中存在污染因子。胰高血糖素对粘膜下小动脉无影响。另外，通过体内显微镜观察胰高血糖素对大鼠粘膜下小动脉（10 ~ 30 μ）的影响。同样，胰高血糖素也没有效果。但是小剂量的去甲肾上腺素会产生血管收缩。
The purpose of the present study was to evaluate the effects of several gastrointestinal hormones on the gastric submucosal arterioles using an in vivo microscopy technique. Alteration in diameter of submucosal arterioles, 40 to 90 µ in diameter, in response to infusion of different agents into the celiac axis, was measured in the anesthetized cat. Pentagastrin, the octapeptide of cholecystokinin, natural secretin, and histamine produced arteriolar dilation. Only with histamine and the octapeptide of cholecystokinin did this occur with doses that might be considered physiological. Synthetic secretin had no vasodilator activity, suggesting the presence of a contaminating agent in natural secretin. Glucagon had no effect on the submucosal arterioles. In addition, the effect of glucagon on the smaller (10 to 30 μ) terminal and subterminal submucosal arterioles was studied in the rat by in vivo microscopy. Again no effect was observed with glucagon. but norepinephrine in small doses produced vasoconstriction.