Methadone treatment for opiate dependent patients in general practice and specialist clinic settings: Outcomes at 2-year follow-up
Methadone treatment for opiate dependent patients in general practice and specialist clinic settings: Outcomes at 2-year follow-up
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DOI：
10.1016/s0740-5472(03)00040-0
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发表时间：
2003-06-01
影响因子：
3.9
通讯作者：
Marsden, J
中科院分区：
文献类型：
--
作者：
Gossop, M;Stewart, D;Marsden, J
很少有研究调查美沙酮治疗阿片类药物依赖患者在初级卫生保健设置。采用前瞻性队列设计，该研究调查了240例在英格兰各地接受全科医生（n = 79）或药物诊所（n = 161）治疗的患者的1年和2年结局。两组的平均每日美沙酮剂量为50 mg。在随访中，两组都发现非法药物使用、注射、共用注射器具、心理和身体健康问题以及犯罪减少。在全科医生（GP）治疗的患者报告苯二氮卓类药物和兴奋剂的使用频率较低，随访时心理健康问题较少。两组的酒精使用结果都很差。全科医生和诊所的治疗实践存在差异。结果显示，在GP和诊所环境中治疗的阿片类药物依赖患者的样本中，一系列问题行为大幅减少，持续到1年和2年的随访。(C)2003年爱思唯尔公司All rights reserved.
Few studies have investigated methadone treatment of opiate dependent patients in primary health care settings. Using a prospective cohort design, the study investigated outcomes at 1 and 2 years for 240 patients treated by general practitioners (n = 79) or drug clinics (n = 161) at sites across England. Mean daily methadone dose for both groups was 50 mg. Reductions in illicit drug use, injecting, sharing injecting equipment, psychological and physical health problems, and crime, were found in both groups at follow-up. Patients treated in general practitioner (GP) settings reported less frequent benzodiazepine and stimulant use, and fewer psychological health problems at follow-up. Alcohol use outcomes were poor for both groups. Differences in treatment practices were found for GPs and clinics. Results show substantial reductions in a range of problems behaviours, among unselected samples of opiate dependent patients treated in GP and in clinic settings, which are sustained to 1-year and 2-year follow-up. (C) 2003 Elsevier Inc. All rights reserved.