Patterns of dysgraphia in primary progressive aphasia compared to post-stroke aphasia.
Patterns of dysgraphia in primary progressive aphasia compared to post-stroke aphasia.
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DOI：
10.3233/ben-2012-110237
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发表时间：
2013
影响因子：
2.8
通讯作者：
Hillis AE
中科院分区：
文献类型：
--
作者：
Faria AV;Crinion J;Tsapkini K;Newhart M;Davis C;Cooley S;Mori S;Hillis AE
我们报告了原发性进行性失语症患者的书写困难模式，这可以通过假设在复杂的拼写过程中一个或多个认知过程或表征的中断来解释。将这些模式与局灶性病变（中风）参与者中描述的模式进行比较。利用结构成像技术，我们发现左侧外侧裂区的损伤，包括钩椎、下额枕束和矢状层。（包括膝状纹状体通路和下纵束），以及其他深部白色和灰质结构，与获得正字法单词形式和语义的障碍显著相关（在拼写听写任务中，依靠语音-正字法来产生合理的拼写）。这些结果不仅有助于我们理解获得性脑损伤后的书写困难模式，也有助于理解拼写背后的神经基质。
We report patterns of dysgraphia in participants with primary progressive aphasia that can be explained by assuming disruption of one or more cognitive processes or representations in the complex process of spelling. These patterns are compared to those described in participants with focal lesions (stroke). Using structural imaging techniques, we found that damage to the left extrasylvian regions, including the uncinate, inferior fronto-occipital fasciculus, and sagittal stratum (including geniculostriate pathway and inferior longitudinal fasciculus), as well as other deep white and grey matter structures, was significantly associated with impairments in access to orthographic word forms and semantics (with reliance on phonology-to-orthography to produce a plausible spelling in the spelling to dictation task). These results contribute not only to our understanding of the patterns of dysgraphia following acquired brain damage but also the neural substrates underlying spelling.