Comparative Analysis of Neutrophil-to-lymphocyte Ratio, Systemic Immune-Inflammation Index, and Prognostic Nutritional Index in Acute Myocardial Infarction Patients Treated with Percutaneous Coronary Intervention
Comparative Analysis of Neutrophil-to-lymphocyte Ratio, Systemic Immune-Inflammation Index, and Prognostic Nutritional Index in Acute Myocardial Infarction Patients Treated with Percutaneous Coronary Intervention
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DOI：
10.5543/tkda.2022.22513
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发表时间：
2022-10-01
影响因子：
0.8
通讯作者：
Kilickesmez, Kadriye
中科院分区：
文献类型：
--
作者：
Kocas, Betul Balaban;Cetinkal, Gokhan;Kilickesmez, Kadriye
目的：急性心肌梗死是心源性死亡的主要原因之一。因此，早期识别高危患者可提供更好的预后准确性。本研究旨在探讨新型炎症生物标志物（如中性粒细胞与淋巴细胞比率、全身免疫炎症指数和预后营养指数）在接受经皮冠状动脉介入治疗的急性心肌梗死患者中的预后意义，并比较它们的预测能力。方法：回顾性分析828例急性心肌梗死患者经皮冠状动脉介入治疗的临床资料。通过入院血液检查计算炎症指标，如嗜中性粒细胞/淋巴细胞比值、全身免疫炎症指数和预后营养指数。结果：多变量考克斯回归分析确定预后营养指数是主要不良心脏事件和全因死亡率的独立预测因子（危险比：1.05，95%CI：1.00，95%CI：1.000，95%CI：1.00，95%CI：1.0 1.02-1.07，P
Objective: Acute myocardial infarction constitutes one of the leading reasons for cardiac mortality. Therefore, early identification of high-risk patients provides better prognostic accuracy. This study aimed to investigate the prognostic significance of novel inflammatory biomarkers such as neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and prognostic nutritional index in acute myocardial infarction patients treated with percutaneous coronary intervention and to compare their predictive abilities with each other.Methods: A total of 828 acute myocardial infarction patients treated with percutaneous coronary intervention were retrospectively analyzed. The inflammatory indices, such as neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and prognostic nutritional index, were calculated by admission blood tests. The study population was divided into 2 groups according to the occurrence of major adverse cardiac events, which were defined as all-cause mortality, non-fatal myocardial infarction, and cerebrovascular events.Results: Multivariate Cox regression analysis determined prognostic nutritional index as an independent predictor of major adverse cardiac event and all-cause mortality (hazard ratio: 1.05, 95% CI: 1.02-1.07, P