The role of stress in colicin regulation
The role of stress in colicin regulation
复制标题
压力在肠毒素调节中的作用
DOI：
10.1007/s00203-014-1017-8
复制
发表时间：
2014-11-01
影响因子：
2.8
通讯作者：
Gillor, Osnat
中科院分区：
文献类型：
--
作者：
Ghazaryan, Lusine;Tonoyan, Lilit;Gillor, Osnat
Bacteriocins produced by Enterobacteriaceae are high molecular weight toxic proteins that kill target cells through a variety of mechanisms, including pore formation and nucleic acid degradation. What is remarkable about these toxins is that their expression results in death to the producing cells and therefore bacteriocin induction have to be tightly regulated, often confined to times of stress. Information on the regulation of bacteriocins produced by enteric bacteria is sketchy as their expression has only been elucidated in a handful of bacteria. Here, we review the known regulatory mechanisms of enteric bacteriocins and explore the expression of 12 of them in response to various triggers: DNA-damaging agents, stringent response, catabolite repression, oxidative stress, growth phase, osmolarity, cold shock, nutrient deprivation, anaerobiosis and pH stress. Our results indicate that the expression of bacteriocins is mostly confined to mutagenic triggers, while all other triggers tested are limited inducers.
