Behavioral evidence for μ-opioid and 5-HT2A receptor interactions
Behavioral evidence for μ-opioid and 5-HT2A receptor interactions
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DOI：
10.1016/s0014-2999(03)01971-x
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发表时间：
2003-08-01
影响因子：
5
通讯作者：
Marek, GJ
中科院分区：
文献类型：
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作者：
Marek, GJ
电生理学研究表明，内侧前额叶皮质中的 5-HT2A 和 mu-阿片受体之间存在生理相互作用。此外，行为研究发现，当直接给予内侧前额叶皮层时，苯乙胺致幻剂会引起摇头。吗啡抑制血清素激动剂引起的摇头的受体尚未被表征。我们在用苯乙胺致幻剂 1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷 (DOI) 治疗之前，对成年雄性 Sprague-Dawley 大鼠施用 g-阿片受体激动剂和拮抗剂，已知该物质可通过 5-HT2A 受体诱导摇头。中选择性 mu-阿片受体激动剂丁丙诺啡（ID50 类似于 0.005 mg/kg，腹腔注射；mu-阿片受体部分激动剂和 kappa-阿片受体拮抗剂）的抑制作用被纳洛酮和不可逆 mu-阿片受体拮抗剂 clocinnamox 预处理所阻断。另一种 mu-阿片受体激动剂芬太尼也能抑制 DOI 引起的摇头。相比之下，δ-阿片受体激动剂对 DOI 引起的摇头没有影响。因此，μ阿片受体的激活可以抑制致幻药物引起的摇头。 (C) 2003 Elsevier B.V. 保留所有权利。
Electrophysiological studies have demonstrated a physiological interaction between 5-HT2A and mu-opioid receptors in the medial prefrontal cortex. Furthermore, behavioral studies have found that phenethylamine hallucinogens induce head shakes when directly administered into the medial prefrontal cortex. The receptor(s) by which morphine suppresses head shakes induced by serotonin agonists have not been characterized. We administered g-opioid receptor agonists and antagonists to adult male Sprague-Dawley rats prior to treatment with the phenethylamine hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), which is known to induce head shakes via 5-HT2A receptors. The suppressant action of the moderately selective mu-opioid receptor agonist, buprenorphine (ID50 similar to 0.005 mg/ kg, i.p.; a mu-opioid receptor partial agonist and kappa-opioid receptor antagonist) was blocked by naloxone and pretreatment with the irreversible mu-opioid receptor antagonist clocinnamox. Another mu-opioid receptor agonist fentanyl also suppressed DOI-induced head shakes. In contrast, a delta-opioid receptor agonist was without effect on DOI-induced head shakes. Thus, activation of mu-opioid receptors can suppress head shakes induced by hallucinogenic drugs. (C) 2003 Elsevier B.V. All rights reserved.