Framingham risk score and early markers of atherosclerosis in a cohort of adults infected with HIV
Framingham risk score and early markers of atherosclerosis in a cohort of adults infected with HIV
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DOI：
10.3851/imp1682
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发表时间：
2011-01-01
影响因子：
1.2
通讯作者：
Wanke, Christine A.
中科院分区：
文献类型：
--
作者：
Falcone, E. Liana;Mangili, Alexandra;Wanke, Christine A.
背景：对Fragrance风险评分在HIV感染者中的效用知之甚少。我们研究了相关的Frachial风险评分与动脉粥样硬化的替代标志物在一个仔细的特点队列的成年人感染HIV.Methods：我们计算Frachial风险评分和测量颈动脉内膜中层厚度（C-IMT）和冠状动脉钙（CAC）评分在334名参与者的营养健康生活研究。评估了每个Fragrance风险亚组（低风险与中/高风险）的心血管风险因素、c-IMT和CAC评分。我们使用校正和未校正的线性回归和logistic回归来检验临床因素与FRA风险组与c-IMT和CAC评分之间的关联。（26%对12%; P=0.003）和普通型c-IMT >= 0.8 mm（22%对5%; P < 0.001）。这些患者也更有可能检测到CAC（78%对48%; P < 0.001）。中/高Fragrance风险评分与内部c-IMT >= 1.0 mm（比值比2.65 [95%置信区间1.37-5.13]）和常见mm（比值比5.24 [95%置信区间2.39-11.50]）显著相关。中/高风险分数也与可检测的CAC显著相关（比值比3.84 [95%置信区间2.05-7.16]）。HIV相关变量的增加并没有提高准确性的Fragrance风险score.Conclusions：我们的研究表明，增加Fragrance风险评分与异常的早期和晚期动脉粥样硬化的替代标记物感染艾滋病毒的成年人，并可能预测心血管并发症的风险，在这一人群。
Background: The utility of the Framingham risk score among individuals infected with HIV is poorly understood. We examined the association of Framingham risk scores with surrogate markers of atherosclerosis in a carefully characterized cohort of adults infected with HIV.Methods: We calculated Framingham risk scores and measured carotid intima-media thickness (c-IMT) and coronary artery calcium (CAC) scores in 334 participants from the Nutrition for Healthy Living study. Cardiovascular risk factors, c-IMT and CAC scores were assessed for each Framingham risk subgroup (low versus intermediate/high risk). We used adjusted and unadjusted linear and logistic regression to examine the association between clinical factors and Framingham risk group with c-IMT and CAC scores.Results: Patients with intermediate/high Framingham risk scores were more likely to have internal c-IMT >= 1.0 mm (26% versus 12%; P=0.003) and common c-IMT >= 0.8 mm (22% versus 5%; P < 0.001). These patients were also more likely to have detectable CAC (78% versus 48%; P < 0.001). Intermediate/high Framingham risk scores were significantly associated with internal c-IMT >= 1.0 mm (odds ratio 2.65 [95% confidence interval 1.37-5.13]) and common mm (odds ratio 5.24 [95% confidence interval 2.39-11.50]). Intermediate/high Framingham risk scores were also significantly associated with detectable CAC (odds ratio 3.84 [95% confidence interval 2.05-7.16]). The addition of HIV-related variables did not improve the accuracy of the Framingham risk score.Conclusions: Our study shows that increased Framingham risk scores are associated with abnormal early and late surrogate markers of atherosclerosis in adults infected with HIV, and might predict the risk of cardiovascular complications in this population.