TH1 cells control themselves by producing interleukin-10
TH1 cells control themselves by producing interleukin-10
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DOI：
10.1038/nri2097
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发表时间：
2007-06-01
影响因子：
100.3
通讯作者：
Vieira, Paulo
中科院分区：
文献类型：
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作者：
O'Garra, Anne;Vieira, Paulo
炎症性T辅助细胞1(T(H)1)-细胞反应成功根除病原体，但通常也引起免疫病理。为了将这种有害的副作用降到最低，产生了抗炎细胞因子白介素10(IL-10)。虽然IL-10最初是从T(H)2细胞中分离出来的，但现在知道它是由许多类型的细胞产生的。在这里，我们讨论最近的证据表明，T(H)1细胞是控制对大利什曼原虫和弓形虫感染的免疫反应的IL-10的主要来源。
Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.