Cell mediated events that control blood coagulation and vascular injury.
Cell mediated events that control blood coagulation and vascular injury.
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DOI：
10.1146/annurev.cb.09.110193.000245
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
C. T. Esmon
中科院分区：
文献类型：
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作者：
C. T. Esmon
最近无标记的研究表明，凝血酶和其他凝血因子的产生在细胞调节中发挥着重要作用，可能在各种疾病过程中也发挥着重要作用。这些细胞反应中的许多发生在凝血酶水平低于纤维蛋白凝块形成所需的水平。更特异的试剂干预凝血过程可能有助于更好地理解凝血级联反应及其抑制物在正常和病理反应中的作用。在不久的将来，对炎症和细胞反应在凝血控制中作用的进一步了解将为预防血栓形成提供许多新的、可能更安全的干预措施。免责声明我在这一章的目的是提供一些膜在血液凝结过程中的作用以及凝血因子在细胞激活中的作用的概述。该领域的范围如此之广，以至于许多重要的贡献被忽视，而且篇幅的限制迫使在许多情况下引用评论而不是主要出版物。我对这些疏忽感到后悔。
UNLABELLED Recent studies suggest that the generation of thrombin and other clotting factors plays a major role in cellular regulation and probably a variety of disease processes. Many of these cellular responses occur at thrombin levels lower than those required for fibrin clot formation. The availability of more specific reagents to intervene in the coagulation process will likely provide a better understanding of the role of the coagulation cascade and its inhibitors in normal and pathologic responses. In the immediate future, improved understanding of the role of inflammation and cellular responses in the control of coagulation offers many new and potentially safer interventions to prevent thrombosis. DISCLAIMER It was my intent in this chapter to provide some outlines of the role of membranes in the blood clotting process and the role of coagulation factors in cellular activation. The scope of the area is so extensive that many important contributions have been overlooked and space limitations forced citation of reviews rather than primary publications in many cases. I regret these oversights.